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SREBF1 gene

Known as: sterol regulatory element binding transcription factor 1, SREBP1a, SREBF1 
This gene is involved in both transcriptional regulation and lipid homeostasis.
National Institutes of Health

Related topics

Related topics

8 relations
Homo sapiensLipid MetabolismSterol Regulatory Element Binding Protein 1Sterol Regulatory Element Binding Protein 1c

Narrower (1)

SREBF1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth.
Dysregulation of the sterol regulatory element-binding transcription factors sterol regulatory element-binding protein (SREBP… 
Highly Cited
2014
Highly Cited
2014
Function of SREBP1 in the Milk Fat Synthesis of Dairy Cow Mammary Epithelial Cells
Sterol regulatory element-binding proteins (SREBPs) belong to a family of nuclear transcription factors. The question of which is… 
2013
2013
Oxymatrine attenuates hepatic steatosis in non-alcoholic fatty liver disease rats fed with high fructose diet through inhibition of sterol regulatory element binding transcription factor 1 (Srebf1…
Highly Cited
2013
Highly Cited
2013
PKR-Like Endoplasmic Reticulum Kinase Is Necessary for Lipogenic Activation during HCMV Infection
PKR-like endoplasmic reticulum (ER) kinase (PERK) is an ER-associated stress sensor protein which phosphorylates eukaryotic… 
Highly Cited
2011
Highly Cited
2011
Mechanism of AMPK Suppression of LXR-dependent Srebp-1c Transcription
Activation of AMP-activated protein kinase (AMPK) inhibits hepatic fatty acid synthesis by suppressing sterol regulatory element… 
Highly Cited
2010
Highly Cited
2010
Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples
Several studies have reported structural brain abnormalities, decreased myelination and oligodendrocyte dysfunction in… 
Highly Cited
2009
Highly Cited
2009
Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios.
BACKGROUND Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the limiting step of monounsaturated fatty acid synthesis in humans… 
2008
2008
Association of Variants in the Sterol Regulatory Element-Binding Factor 1 (SREBF1) Gene With Type 2 Diabetes, Glycemia, and Insulin Resistance
OBJECTIVE—We evaluated the association of variants in the sterol regulatory element-binding factor 1 gene (SREBF1) with type 2… 
Highly Cited
2006
Highly Cited
2006
Cdk1/Cyclin B-Mediated Phosphorylation Stabilizes SREBP1 During Mitosis
Members of the sterol regulatory element-binding protein (SREBP) family of transcription factors control the biosynthesis of… 
Highly Cited
2004
Highly Cited
2004
Inhibition of Histone Deacetylase Activity by Valproic Acid Blocks Adipogenesis*
Adipogenesis is dependent on the sequential activation of transcription factors including the CCAAT/enhancer-binding proteins (C… 
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