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Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells.
Fatty acid synthetase (FAS) is overexpressed in various tumor tissues, and its inhibition and/or malonyl-CoA accumulation have been correlated to apoptosis of tumor cells. It is widely recognizedExpand
Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome.
Chronic fatigue syndrome (CFS) is a poorly understood disease characterized by mental and physical fatigue, most often observed in young white females. Muscle pain at rest, exacerbated by exercise,Expand
Molecular defects in sarcolemmal glycerophospholipid subclasses in diabetic cardiomyopathy.
Although still scarcely studied, the phospholipid component of the cell membrane is of absolute importance for cell function. Experimental evidence indicates that individual molecular species of aExpand
Eicosapentaenoic Acid Demethylates a Single CpG That Mediates Expression of Tumor Suppressor CCAAT/Enhancer-binding Protein δ in U937 Leukemia Cells*
Polyunsaturated fatty acids (PUFAs) inhibit proliferation and induce differentiation in leukemia cells. To investigate the molecular mechanisms whereby fatty acids affect these processes, U937Expand
A diet supplemented with ALA-rich flaxseed prevents cardiomyocyte apoptosis by regulating caveolin-3 expression.
AIMS n-3 polyunsaturated fatty acids (PUFAs) induce beneficial effects on the heart, but the mechanisms through which these effects are operated are not completely clarified yet. Among others,Expand
An omega-3 fatty acid-enriched diet prevents skeletal muscle lesions in a hamster model of dystrophy.
Currently, despite well-known mutational causes, a universal treatment for neuromuscular disorders is still lacking, and current therapeutic efforts are mainly restricted to symptomatic treatments.Expand
Enhanced expression of hepatic lipogenic enzymes in an animal model of sedentariness Published, JLR Papers in Press, January 16, 2003. DOI 10.1194/jlr.M200252-JLR200
The hindlimb-suspended rat was used as animal model to investigate the effects induced by immobilization of the skeletal muscle in the expression of the genes encoding hepatic lipogenic enzymes.Expand
Eicosapentaenoic acid induces DNA demethylation in carcinoma cells through a TET1‐dependent mechanism
In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes.Expand
Alpha-linolenic acid-enriched diet prevents myocardial damage and expands longevity in cardiomyopathic hamsters.
Randomized clinical trials have demonstrated that the increased intake of omega-3 polyunsaturated fatty acids significantly reduces the risk of ischemic cardiovascular disease, but no investigationsExpand
Identification of a new missense mutation in the mtDNA of hereditary hypertrophic, but not dilated cardiomyopathic hamsters
The cardiomyopathic hamster is characterized by a naturally occurring deletion in the δ-sarcoglycan gene generating either the hypertrophic or the dilatative phenotype of cardiomyopathy. ThisExpand
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