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SPN protein, human

Known as: CD43, LSGP protein, human, Leukosialin 
Leukosialin (400 aa, ~40 kDa) is encoded by the human SPN gene. This protein is involved in immune cell function.
National Institutes of Health

Related topics

Related topics

16 relations
Antibacterial ResponseBlood coagulationCell Adhesion InhibitionChemotaxis

Broader (1)

CD43 Antigen

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
CD43 Plays Both Antiadhesive and Proadhesive Roles in Neutrophil Rolling in a Context-Dependent Manner1
As the first step in the recruitment of neutrophils into tissues, the cells become tethered to and roll on the vessel wall. These… 
Highly Cited
2002
Highly Cited
2002
Dynamic Regulation of T Cell Immunity by CD431
During a viral response, Ag-specific effector T cells show dramatically increased binding by the mAb 1B11 and the lectin peanut… 
Highly Cited
2000
Highly Cited
2000
A Macrophage Invasion Mechanism for Mycobacteria Implicating the Extracellular Domain of Cd43
We studied the role of CD43 (leukosialin/sialophorin), the negatively charged sialoglycoprotein of leukocytes, in the binding of… 
Review
1999
Review
1999
CD43, a molecule with multiple functions
To initiate a specific immune response, lymphoid cells integrate a variety of signals generated through the orchestrated… 
Highly Cited
1993
Highly Cited
1993
CD43, the major sialoglycoprotein of human leukocytes, is proteolytically cleaved from the surface of stimulated lymphocytes and granulocytes.
CD43, the major sialoglycoprotein of human leukocytes, whose expression is defective in patients with the Wiskott-Aldrich… 
Highly Cited
1992
Highly Cited
1992
CD43 interferes with T-lymphocyte adhesion.
CD43 is a cell-surface sialoglycoprotein of uncertain physiologic function expressed to various degrees by most leukocytes. We… 
1992
1992
Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin).
The amino acid sequence of galactoglycoprotein purified from human plasma was elucidated to 75% completeness by using chemical… 
Highly Cited
1990
Highly Cited
1990
Signal transduction via leukocyte antigen CD43 (sialophorin). Feedback regulation by protein kinase C.
CD43 is a constitutively phosphorylated 115-kDa sialoglycoprotein expressed on a variety of blood cells including lymphocytes and… 
Highly Cited
1989
Highly Cited
1989
Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome.
Sialophorin (CD43) of leukocytes and platelets is a surface sialoglycoprotein that is phenotypically defective on lymphocytes of… 
Highly Cited
1989
Highly Cited
1989
Phosphorylation of the major leukocyte surface sialoglycoprotein, leukosialin, is increased by phorbol 12-myristate 13-acetate.
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