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SPHK1 gene

Known as: Sphingosine Kinase 1 Gene, SPHINGOSINE KINASE 1, SPHK1 
This gene plays a role in lipid phosphorylation and signal transduction.
National Institutes of Health

Related topics

Related topics

10 relations
Angiogenic ProcessCalcium SignalingNegative Regulation of ApoptosisPhospholipid Metabolism

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SPHK1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Reduction of COX-2 through modulating miR-124/SPHK1 axis contributes to the antimetastatic effect of alpinumisoflavone in melanoma.
Alpinumisoflavone (AIF) is a naturally occurring flavonoid that is a major bioactive component of the medicinal plant Derris… 
2016
2016
α-Melanocyte stimulating hormone attenuates dexamethasone-induced osteoblast damages through activating melanocortin receptor 4-SphK1 signaling.
Highly Cited
2015
Highly Cited
2015
MicroRNA-101 down-regulates sphingosine kinase 1 in colorectal cancer cells.
Highly Cited
2014
Highly Cited
2014
Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity.
Erythrocyte possesses high sphingosine kinase 1 (SphK1) activity and is the major cell type supplying plasma sphingosine-1… 
2014
2014
Sphingosine kinase 1 contributes to leptin-induced STAT3 phosphorylation through IL-6/gp130 transactivation in oestrogen receptor-negative breast cancer
Obesity is a known risk factor for breast cancer. We have recently identified that adipokine leptin regulates the expression of a… 
2012
2012
The Role of Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in the Myogenic Tone of Posterior Cerebral Arteries
Aims The goal of the current study was to determine whether the sphingosine kinase 1 (SK1)/sphingosine-1-phosphate (S1P) pathway… 
2007
2007
RET signaling‐induced SPHK1 gene expression plays a role in both GDNF‐induced differentiation and MEN2‐type oncogenesis
RET, the receptor of glial cell line‐derived neurotrophic factor (GDNF) family ligands, is important for the development of… 
Highly Cited
2005
Highly Cited
2005
Novel role of sphingosine kinase 1 as a mediator of neurotrophin‐3 action in oligodendrocyte progenitors
We had found previously that neurotrophin‐3 (NT‐3) is a potent stimulator of cAMP‐response element binding protein (CREB… 
Highly Cited
2004
Highly Cited
2004
Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1.
Sphingosine kinase (SPHK) is a key enzyme catalysing the formation of sphingosine 1-phosphate (SPP), a lipid messenger that is… 
2004
2004
Identification of PECAM-1 association with sphingosine kinase 1 and its regulation by agonist-induced phosphorylation.
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