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SPHK1 gene

Known as: Sphingosine Kinase 1 Gene, SPHINGOSINE KINASE 1, SPHK1 
This gene plays a role in lipid phosphorylation and signal transduction.
National Institutes of Health

Related topics

Related topics

10 relations
Angiogenic ProcessCalcium SignalingNegative Regulation of ApoptosisPhospholipid Metabolism

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SPHK1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid mediator, has been implicated in regulation of many processes important… 
Highly Cited
2012
Highly Cited
2012
miR‐124 inhibits cell proliferation in gastric cancer through down‐regulation of SPHK1
SPHK1 expression is elevated in gastric cancer and is associated with shorter survival times for patients. However, the molecular… 
Highly Cited
2012
Highly Cited
2012
Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis
Mechanisms by which cancer cells communicate with the host organism to regulate lung colonization/metastasis are unclear. We show… 
Highly Cited
2011
Highly Cited
2011
Sphingosine Kinase 1 and Sphingosine 1-Phosphate Receptor 3 Are Functionally Upregulated on Astrocytes under Pro-Inflammatory Conditions
Background Reactive astrocytes are implicated in the development and maintenance of neuroinflammation in the demyelinating… 
Highly Cited
2010
Highly Cited
2010
High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in…
Various studies in cell lines have previously demonstrated that sphingosine kinase 1 (SK1) and extracellular signal-regulated… 
Highly Cited
2009
Highly Cited
2009
Sphingosine Kinase 1 Is Associated with Gastric Cancer Progression and Poor Survival of Patients
Purpose: The present study was to investigate the clinical significance of sphingosine kinase 1 (SPHK1), an oncoenzyme, in the… 
Highly Cited
2006
Highly Cited
2006
Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice
Highly Cited
2004
Highly Cited
2004
Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720*
Sphingosine-1-phosphate (S1P), a lipid signaling molecule that regulates many cellular functions, is synthesized from sphingosine… 
Highly Cited
2003
Highly Cited
2003
Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1.
Highly Cited
2002
Highly Cited
2002
The Nucleotide-binding Site of Human Sphingosine Kinase 1*
Sphingosine kinase catalyzes the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in a… 
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