SNAP7941

Known as: SNAP-7941 
 
National Institutes of Health

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PiperidinesPyrimidines

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2016
2016
[(18)F]FE@SNAP-a specific PET tracer for melanin-concentrating hormone receptor 1 imaging?
BACKGROUND The melanin-concentrating hormone receptor 1 (MCHR1), which is highly expressed in the lateral hypothalamus, plays a… (More)
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2013
2013
Preclinical in vitro &in vivo evaluation of [(11)C]SNAP-7941 - the first PET tracer for the melanin concentrating hormone receptor 1.
INTRODUCTION Due to its involvement in a variety of pathologies (obesity, diabetes, gut inflammation and depression), the melanin… (More)
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2012
2012
Radiosynthesis of [11C]SNAP-7941—the first PET-tracer for the melanin concentrating hormone receptor 1 (MCHR1)
The melanin concentrating hormone (MCH) system is a new target to treat human disorders. Our aim was the preparation of the first… (More)
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2010
2010
The endogenous actions of hypothalamic peptides on brown adipose tissue thermogenesis in the rat.
Although the neuronal pathways within the hypothalamus critical in controlling feeding and energy expenditure and projecting to… (More)
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2010
2010
Two naturally occurring mutations in the type 1 melanin-concentrating hormone receptor abolish agonist-induced signaling.
The melanin-concentrating hormone (MCH) receptor type 1 (MCHR1) is a seven-transmembrane domain protein that modulates orexigenic… (More)
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2008
2008
The melanin-concentrating hormone1 receptor antagonists, SNAP-7941 and GW3430, enhance social recognition and dialysate levels of acetylcholine in the frontal cortex of rats.
Melanin-concentrating hormone (MCH)1 receptors are widely expressed in limbic structures and cortex. Their inactivation is… (More)
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2008
2008
Enantioselective synthesis of SNAP-7941: chiral dihydropyrimidone inhibitor of MCH1-R.
An enantioselective synthesis of SNAP-7941, a potent melanin concentrating hormone receptor antagonist, was achieved by using two… (More)
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2006
2006
Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety.
The aim of this study was to validate melanin-concentrating hormone (MCH)-1 receptor antagonism as a potential treatment of mood… (More)
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2006
2006
Development of a time-resolved fluorometric assay for the high throughput screening of melanin concentrating hormone receptor antagonists.
INTRODUCTION Melanin concentrating hormone is an orexigenic hypothalamic neuropeptide, which plays an important role in the… (More)
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2002
2002
Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist
Melanin concentrating hormone (MCH) is an orexigenic hypothalamic neuropeptide, which plays an important role in the complex… (More)
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