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SMYD3 wt Allele

Known as: FLJ21080, ZMYND1, SET and MYND Domain Containing 3 wt Allele 
Human SMYD3 wild-type allele is located in the vicinity of 1q44 and is approximately 758 kb in length. This allele, which encodes SET and MYND domain… 
National Institutes of Health

Related topics

Related topics

9 relations
1q44Cell ProliferationMethylationSMYD3 protein, human

Broader (1)

SMYD3 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
SMYD3 promotes the epithelial–mesenchymal transition in breast cancer
Abstract SMYD3 is a methylase previously linked to cancer cell invasion and migration. Here we show that SMYD3 favors TGF… 
Highly Cited
2015
Highly Cited
2015
SMYD3 contributes to a more aggressive phenotype of prostate cancer and targets Cyclin D2 through H4K20me3
Prostate cancer (PCa) is one of the most incident cancers worldwide but clinical and pathological parameters have limited ability… 
Highly Cited
2013
Highly Cited
2013
The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy.
Elucidating the epigenetic mechanisms underlying muscle mass determination and skeletal muscle wasting holds the potential of… 
Highly Cited
2012
Highly Cited
2012
Epigenetic regulation of miR‐124 by Hepatitis C Virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3
Highly Cited
2012
Highly Cited
2012
SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9.
Upregulation of the matrix metalloproteinase (MMP)-9 plays a central role in tumor progression and metastasis by stimulating cell… 
Highly Cited
2012
Highly Cited
2012
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation
Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4… 
Highly Cited
2011
Highly Cited
2011
Smyd3 Is Required for the Development of Cardiac and Skeletal Muscle in Zebrafish
Modifications of histone tails are involved in the regulation of a wide range of biological processes including cell cycle, cell… 
Highly Cited
2009
Highly Cited
2009
Requirement of Histone Methyltransferase SMYD3 for Estrogen Receptor-mediated Transcription*
SMYD3 is a SET domain-containing protein with histone methyltransferase activity on histone H3–K4. Recent studies showed that… 
Highly Cited
2009
Highly Cited
2009
Knockdown of SMYD3 by RNA interference down-regulates c-Met expression and inhibits cells migration and invasion induced by HGF.
Highly Cited
2006
Highly Cited
2006
Enhanced SMYD3 expression is essential for the growth of breast cancer cells
We previously reported that upregulation of SMYD3, a histone H3 lysine‐4‐specific methyltransferase, plays a key role in the… 
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