SMUG1 gene

Known as: SMUG1, SINGLE-STRAND-SELECTIVE MONOFUNCTIONAL URACIL-DNA GLYCOSYLASE 1, HMUDG 
 
National Institutes of Health

Papers overview

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2014
2014
Excision of uracil introduced into the immunoglobulin loci by AID is central to antibody diversification. While predominantly… (More)
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2007
2007
DNA glycosylases UNG and SMUG1 excise uracil from DNA and belong to the same protein superfamily. Vertebrates contain both SMUG1… (More)
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2007
2007
5-Fluorouracil (FU) has been widely used for more than four decades in the treatment of a range of common cancers. The fluorine… (More)
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Highly Cited
2007
Highly Cited
2007
The Vpr accessory protein of HIV-1 induces a response similar to that of DNA damage. In cells expressing Vpr, the DNA damage… (More)
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2007
2007
Activation-induced deaminase (AID) catalyses deamination of deoxycytidine to deoxyuridine within immunoglobulin loci, triggering… (More)
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2006
2006
Mammals harbour multiple enzymes capable of excising uracil from DNA, although their distinct physiological roles remain… (More)
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2006
2006
The observation that germline mutations in the oxidative DNA damage repair gene MUTYH cause colorectal cancer (CRC) provides… (More)
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2005
2005
The most common genetic change in aerobic organisms is a C:G to T:A mutation. C --> T transitions can arise through spontaneous… (More)
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Review
2002
Review
2002
Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which… (More)
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Highly Cited
2001
Highly Cited
2001
Gene-targeted mice deficient in the evolutionarily conserved uracil-DNA glycosylase encoded by the UNG gene surprisingly lack the… (More)
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