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Human endonuclease V as a repair enzyme for DNA deamination.
The human endonuclease V gene is located in chromosome 17q25.3 and encodes a 282 amino acid protein that shares about 30% sequence identity with bacterial endonuclease V. This study reportsExpand
Binding Analysis of Methyl-CpG Binding Domain of MeCP2 and Rett Syndrome Mutations.
Methyl-CpG binding protein 2 (MeCP2) binds to methylated cytosine in CpG island through its methyl-CpG binding domain (MBD). Here, the effects of the Rett syndrome-causing missense mutations onExpand
Screening of nitrosative stress resistance genes in Coxiella burnetii: Involvement of nucleotide excision repair.
Coxiella burnetii, an obligate intracellular Gram-negative bacterium, is the etiological agent of Q fever. This work takes advantage of a hypersensitive Escherichia coli genetic system to identifyExpand
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair
Endonuclease V (EndoV) initiates a major base-repair pathway for nitrosative deamination resulting from endogenous processes and increased by oxidative stress from mitochondrial dysfunction orExpand
Oxanine DNA Glycosylase Activity from Mammalian Alkyladenine Glycosylase*
Oxanine (Oxa) is a deaminated base lesion derived from guanine in which the N1-nitrogen is substituted by oxygen. This work reports the mutagenicity of oxanine as well as oxanine DNA glycosylaseExpand
Endonuclease V: an unusual enzyme for repair of DNA deamination
  • Weiguo Cao
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
  • 1 September 2013
Endonuclease V (endo V) was first discovered as the fifth endonuclease in Escherichia coli in 1977 and later rediscovered as a deoxyinosine 3′ endonuclease. Decades of biochemical and geneticExpand
Cleavage of deoxyoxanosine-containing oligodeoxyribonucleotides by bacterial endonuclease V.
Oxanine (O) is a deamination product derived from guanine with the nitrogen at the N1 position substituted by oxygen. Cytosine, thymine, adenine, guanine as well as oxanine itself can be incorporatedExpand
Stresses, Aging, and Age-Related Disorders
This special issue focuses on the topics of aging and its related disorders and stress. Stress, defined as a pressure or tension on a subject, can be in any of many forms. As related to aging, twoExpand
Understanding and predicting synthetic lethal genetic interactions in Saccharomyces cerevisiae using domain genetic interactions
We demonstrated that yeast synthetic lethal genetic interactions can be explained by the genetic interactions between domains of those proteins. Expand
New Family of Deamination Repair Enzymes in Uracil-DNA Glycosylase Superfamily*
DNA glycosylases play a major role in the repair of deaminated DNA damage. Previous investigations identified five families within the uracil-DNA glycosylase (UDG) superfamily. All enzymes within theExpand