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Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair
Tight binding by the lesion-recognition pocket in addition to Mg2+ and hydrogen-bonding interactions to the DNA ends stabilize the product complex, suggesting an orderly recruitment of downstream proteins in this base-repair pathway.
Human endonuclease V as a repair enzyme for DNA deamination.
Binding Analysis of Methyl-CpG Binding Domain of MeCP2 and Rett Syndrome Mutations.
- Ye Yang, Tugba G. Kucukkal, Jing Li, E. Alexov, Weiguo Cao
- Biology, ChemistryACS chemical biology
- 8 August 2016
Analysis of the effects of the Rett syndrome-causing missense mutations on binding affinity of MeCP2-MBD finds R111 emerges as the key structural element that modulates the specific contacts with mCpG.
Screening of nitrosative stress resistance genes in Coxiella burnetii: Involvement of nucleotide excision repair.
Oxanine DNA Glycosylase Activity from Mammalian Alkyladenine Glycosylase*
- Thomas M Hitchcock, Liang Dong, Weiguo Cao
- Biology, ChemistryJournal of Biological Chemistry
- 10 September 2004
AAG is a mammalian enzyme that can act on all three purine deamination bases, hypoxanthine, xanthine and oxanine, and AAG can also remove 1,N6-ethenoadenine from single-stranded DNA.
Endonuclease V: an unusual enzyme for repair of DNA deamination
- Weiguo Cao
- BiologyCellular and Molecular Life Sciences
- 1 September 2013
This review is intended to provide a comprehensive account of the historic aspects, biochemical, structural biological, genetic and biotechnological studies of this unusual DNA repair enzyme.
Recent developments in ligase-mediated amplification and detection.
- Weiguo Cao
- BiologyTrends in biotechnology
Cleavage of deoxyoxanosine-containing oligodeoxyribonucleotides by bacterial endonuclease V.
Hypothetic models of oxanine-containing base pairs and deaminated base recognition mechanism are presented and the cleavage of double-stranded oxanosine- containing DNA was approximately 6-fold less efficient than that ofdouble-Stranded inosine-contained DNA.
Islet Amyloid Polypeptide Promotes Amyloid-Beta Aggregation by Binding-Induced Helix-Unfolding of the Amyloidogenic Core.
- Xinwei Ge, Ye Yang, Yunxiang Sun, Weiguo Cao, Feng Ding
- Biology, ChemistryACS chemical neuroscience
- 29 January 2018
Simulation results suggest that peptides in the mixture tend to form heterodimers as the first step toward their coaggregation, and propose that soluble IAPP promotes the aggregation of Aβ42 by binding-induced conformational change of A β42 in its amyloidogenic core and thus reduced aggregation free-energy barrier.
Carbon nutrition and hydrolytic and cellulolytic activities in the ectomycorrhizal fungus Pisolithus tinctorius
Four strains of an ectomycorrhizal fungus were investigated for carbon nutrition, and for production of hydrolytic and cellulolytic enzymes, and it was indicated that acid 0-glucosidase was expressed constitutively, with increased activity in cellobiose-containing media.