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SMG6 gene

Known as: SMG6 nonsense mediated mRNA decay factor, KIAA0732, SMG-6 
National Institutes of Health

Papers overview

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Review
2015
Review
2015
Unique Aspects of Plant Nonsense-Mediated mRNA Decay.
Highly Cited
2014
Highly Cited
2014
A post-translational regulatory switch on UPF1 controls targeted mRNA degradation
Nonsense-mediated mRNA decay (NMD) controls the quality of eukaryotic gene expression and also degrades physiologic mRNAs. Here… 
Highly Cited
2014
Highly Cited
2014
Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells
In metazoans, cleavage by the endoribonuclease SMG6 is often the first degradative event in non-sense-mediated mRNA decay (NMD… 
Highly Cited
2014
Highly Cited
2014
A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD
Eukaryotic mRNAs with premature translation-termination codons (PTCs) are recognized and eliminated by nonsense-mediated mRNA… 
Highly Cited
2013
Highly Cited
2013
The SMG5–SMG7 heterodimer directly recruits the CCR4–NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2
Nonsense-mediated mRNA decay (NMD) is a quality control mechanism to detect aberrant mRNAs and induce their degradation. Loh et… 
Highly Cited
2006
Highly Cited
2006
The Human RNA Surveillance Factor UPF1 Is Required for S Phase Progression and Genome Stability
Highly Cited
2006
Highly Cited
2006
Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex
SMG6 and SMG5 are essential factors in nonsense‐mediated mRNA decay, a conserved pathway that degrades mRNAs with premature… 
Review
2006
Review
2006
The Double Life of UPF1 in RNA and DNA Stability Pathways
The DNA and RNA helicase UPF1 is well known for its central role in Nonsense Mediated RNA Decay (NMD), which promotes degradation… 
Highly Cited
2005
Highly Cited
2005
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.
Highly Cited
2005
Highly Cited
2005
Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets.
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that degrades mRNAs containing nonsense codons, and regulates the… 
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