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Structural basis of Aurora-A activation by TPX2 at the mitotic spindle.
The recognition between Aurora-A and TPX2 resembles that between the cAPK catalytic core and its flanking regions, suggesting this molecular mechanism may be a recurring theme in kinase regulation. Expand
Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α
The crystal structure of a 50 kDa fragment of the 60 kDa yeast karyopherin alpha is reported, which reveals the determinants of NLS specificity and suggests a model for the recognition of bipartite NLSs. Expand
The Crystal Structure of the Exon Junction Complex Reveals How It Maintains a Stable Grip on mRNA
Comparison with the structure of the eIF4AIII-Btz subcomplex that is determined reveals that large conformational changes are required upon EJC assembly and disassembly. Expand
Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2.
Upf1 is a crucial factor in nonsense-mediated mRNA decay, the eukaryotic surveillance pathway that degrades mRNAs containing premature stop codons. The essential RNA-dependent ATPase activity of Upf1Expand
A single subunit, Dis3, is essentially responsible for yeast exosome core activity
It is observed that the yeast exosome ring mediates interactions with protein partners, providing an explanation for its essential function. Expand
Structural biology of nucleocytoplasmic transport.
The molecular mechanisms underlying nucleocytoplasmic transport as they have been revealed by structural studies of the receptors and regulators in different steps of transport cycles are described. Expand
Structure of a Survivin–Borealin–INCENP Core Complex Reveals How Chromosomal Passengers Travel Together
This work determined the 1.4 A resolution crystal structure of the regulatory core of the CPC, revealing that Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle. Expand
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway.
The crystal structure of the N-terminal domain of SMG7 is reported, revealing that it contains a 14-3- 3-like domain and implying that the homologous human Est1 might have a 14 -3-3 function at telomeres, and that phosphorylation events may be important for telomerase regulation. Expand
Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression.
Structural and biochemical approaches revealed that CNOT1 modulates the conformation of DDX6 and stimulates ATPase activity, and provided insights into the repressive steps downstream of the GW182/TNRC6 proteins and the role of the CCR4-NOT complex in posttranscriptional regulation in general. Expand
Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes.
Firefly luciferase is the first member of a superfamily of homologous enzymes, which includes acyl-coenzyme A ligases and peptide synthetases, to have its structure characterized. Expand