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SMAD3 gene

Known as: SMAD, Mothers Against DPP Homolog 3 (Drosophila) Gene, SMAD3, MOTHERS AGAINST DECAPENTAPLEGIC, DROSOPHILA, HOMOLOG OF, 3 
This gene is involved in signal transduction and apoptosis. It also plays a role in the regulation of both steroid synthesis and T-cell response.
National Institutes of Health

Related topics

Related topics

3 relations
SMAD3 protein, humanSignal TransductionTranscriptional Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGFβR2/phosph-SMAD3 axis
Circular RNAs (circRNAs) represent a class of non-coding RNAs (ncRNAs) which are widely expressed in mammals and tissue-specific… 
Highly Cited
2019
Highly Cited
2019
Long noncoding RNA Crnde attenuates cardiac fibrosis via Smad3‐Crnde negative feedback in diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM)—ventricular dysfunction in the absence of underlying heart disease—is a common complication of… 
Highly Cited
2016
Highly Cited
2016
Sirtuin 3 Deregulation Promotes Pulmonary Fibrosis
Oxidative stress leads to alveolar epithelial cell injury and fibroblast-myofibroblast differentiation (FMD), key events in the… 
Highly Cited
2015
Highly Cited
2015
CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation
C1q/tumor necrosis factor-related protein-3 (CTRP3) is a novel adipokine with modulation effects on metabolism, inflammation, and… 
Highly Cited
2015
Highly Cited
2015
MicroRNA-16-5p Controls Development of Osteoarthritis by Targeting SMAD3 in Chondrocytes.
MicroRNAs (miRNA), small noncoding RNA molecules, are endogenous regulators of gene expression that have been implicated in the… 
Highly Cited
2011
Highly Cited
2011
Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet
OBJECTIVE Obesity and associated pathologies are major global health problems. Transforming growth factor-β/Smad3 signaling has… 
Highly Cited
2011
Highly Cited
2011
TRB3 interacts with SMAD3 promoting tumor cell migration and invasion
Tribbles homolog 3 (TRB3, also known as TRIB3, NIPK and SKIP3), a human homolog of Drosophila Tribbles, has been found to… 
Highly Cited
2006
Highly Cited
2006
Tissue array analysis of expression microarray candidates identifies markers associated with tumor grade and outcome in serous epithelial ovarian cancer
Molecular profiling is a powerful approach to identify potential clinical markers for diagnosis and prognosis as well as… 
Highly Cited
2004
Highly Cited
2004
Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells.
The activins are pleiotropic members of the TGFbeta superfamily. Within the anterior pituitary gland, activins stimulate FSH… 
Highly Cited
1998
Highly Cited
1998
SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.
The human type VII collagen gene (COL7A1) recently has been identified as an immediate-early response gene for transforming… 
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