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SMAD3 gene

Known as: SMAD, Mothers Against DPP Homolog 3 (Drosophila) Gene, SMAD3, MOTHERS AGAINST DECAPENTAPLEGIC, DROSOPHILA, HOMOLOG OF, 3 
This gene is involved in signal transduction and apoptosis. It also plays a role in the regulation of both steroid synthesis and T-cell response.
National Institutes of Health

Related topics

Related topics

3 relations
SMAD3 protein, humanSignal TransductionTranscriptional Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
MicroRNA-15b silencing inhibits IL-1β-induced extracellular matrix degradation by targeting SMAD3 in human nucleus pulposus cells
ObjectivesTo determine the role of microRNA-15b (miR-15b) in interleukin-1 beta (IL-1β)-induced extracellular matrix (ECM… 
2015
2015
Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist inhibits collagen synthesis in human hypertrophic scar fibroblasts by targeting Smad3 via miR-145.
2014
2014
Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor β1 in mice.
2014
2014
Akt Suppression of TGFβ Signaling Contributes to the Maintenance of Vascular Identity in Embryonic Stem Cell‐Derived Endothelial Cells
The ability to generate and maintain stable in vitro cultures of mouse endothelial cells (ECs) has great potential for genetic… 
2014
2014
Targeting SMAD3 for inhibiting prostate cancer metastasis
Although SMAD3 signaling has been suggested to play a role in the metastasis of various cancers, its possible involvement as well… 
2013
2013
A SMAD3 gene polymorphism is related with osteoarthritis in a Northeast Chinese population
Variants in the SMAD family member 3 (SMAD3) have recently been reported to be associated with osteoarthritis (OA) in European… 
2012
2012
Evidence for the dysregulated expression of TWIST1, TGFβ1 and SMAD3 in differentiating osteoblasts from primary hip osteoarthritis patients.
2010
2010
Glycogen synthase kinase-3beta negatively regulates TGF-beta1 and Angiotensin II-mediated cellular activity through interaction with Smad3.
2007
2007
Smad3 -signalling and Th2 cytokines in normal mouse airways and in a mouse model of asthma
This study investigates the role of Smad3 signalling for the T-helper2 (Th2) cytokine homeostasis in normal lungs and in a mouse… 
Highly Cited
2002
Highly Cited
2002
Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors.
Transforming growth factor-beta (TGF-beta) represses surfactant protein B (Sp-B) gene transcription through a mechanism that… 
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