• Publications
  • Influence
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF‐β
SMAD3 is one of the intracellular mediators that transduces signals from transforming growth factor‐β (TGF‐β) and activin receptors. We show that SMAD3 mutant mice generated by gene targeting dieExpand
  • 756
  • 33
  • PDF
The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGFβ Family Type I Receptors
The immunophilin FKBP12 is an evolutionarily conserved abundant protein; however, its physiological roles remain poorly defined. Here we report that FKBP12 is a common cytoplasmic interactor of TGFExpand
  • 346
  • 14
Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels.
The zebrafish mutant violet beauregarde (vbg) can be identified at two days post-fertilization by an abnormal circulation pattern in which most blood cells flow through a limited number of dilatedExpand
  • 299
  • 13
  • PDF
Targeted mutagenesis of Smad1 reveals an essential role in chorioallantoic fusion.
The Smad family of intracellular signaling intermediates transduce signals downstream from the transforming growth factor beta (TGF-beta) family of receptor serine threonine kinases. The originalExpand
  • 184
  • 13
  • PDF
RhoA Modulates Smad Signaling during Transforming Growth Factor-β-induced Smooth Muscle Differentiation*
We recently reported that transforming growth factor (TGF)-β induced the neural crest stem cell line Monc-1 to differentiate into a spindle-like contractile smooth muscle cell (SMC) phenotype andExpand
  • 143
  • 12
Transforming growth factor-beta-induced differentiation of smooth muscle from a neural crest stem cell line.
During vascular development, nascent endothelial networks are invested with a layer of supporting cells called pericytes in capillaries or smooth muscle in larger vessels. The cellular lineage ofExpand
  • 62
  • 8
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.
Much progress has been made in elucidating early events in signal transduction by growth factor receptors with intrinsic tyrosine kinase activity. Upon ligand addition, these receptors dimerize andExpand
  • 294
  • 7
Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases.
SMAD proteins mediate signals from receptor serine-threonine kinases (RSKs) of the TGF-beta superfamily. We demonstrate here that HGF and EGF, which signal through RTKs, can also mediateExpand
  • 294
  • 7
  • PDF
Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia.
PURPOSE To conduct a phase I dose-escalation trial assessing safety and response of recombinant immunotoxin moxetumomab pasudotox (CAT-8015, HA22) in chemotherapy-resistant hairy cell leukemia (HCL).Expand
  • 245
  • 7
Transforming Growth Factor-β–Induced Differentiation of Smooth Muscle From a Neural Crest Stem Cell Line
During vascular development, nascent endothelial networks are invested with a layer of supporting cells called pericytes in capillaries or smooth muscle in larger vessels. The cellular lineage ofExpand
  • 159
  • 6
  • PDF