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SMAD2 gene
Known as:
SMAD family member 2
, SMAD2
, MOTHERS AGAINST DECAPENTAPLEGIC, DROSOPHILA, HOMOLOG OF, 2
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This gene plays a role in signal transduction and repression of transcription.
Topic mentions per year
Topic mentions per year
1996-2018
0
10
20
1996
2018
Related topics
Related topics
9 relations
Cell Differentiation process
Cell Proliferation Regulatory Process
Colorectal Carcinoma
Homo sapiens
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Narrower (1)
SMAD2 wt Allele
Related mentions per year
Related mentions per year
1937-2018
1940
1960
1980
2000
2020
SMAD2 gene
Signal Transduction
Colorectal Carcinoma
Cell Differentiation process
dna binding
Homo sapiens
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer.
Nicholas I. Fleming
,
Robert N. Jorissen
,
+22 authors
Oliver M. Sieber
Cancer research
2013
Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in the normal intestinal epithelium…
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2012
2012
MiR-17-92 cluster regulates cell proliferation and collagen synthesis by targeting TGFB pathway in mouse palatal mesenchymal cells.
Ling Li
,
Jia-Yu Shi
,
Gui-quan Zhu
,
Bing Shi
Journal of cellular biochemistry
2012
Elongation and elevation of palatal shelves, mainly caused by proliferation and extra-cellular matrix synthesis of palatal…
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2011
2011
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma.
Michal Grzmil
,
P. Morin
,
+5 authors
Brian A. Hemmings
Cancer research
2011
Glioblastoma multiforme (GBM) is the most common aggressive brain cancer with a median survival of approximately 1 year. In a…
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Highly Cited
2010
Highly Cited
2010
MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-{beta}.
Fethi Louafi
,
Rocio T Martinez-Nunez
,
Tilman Sánchez-Elsner
The Journal of biological chemistry
2010
Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with important effects on processes such as fibrosis…
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2010
2010
SMAD2 is essential for TGF beta-mediated Th17 cell generation.
Nidhi Malhotra
,
Elizabeth J Robertson
,
Joonsoo Kang
The Journal of biological chemistry
2010
TGFβ is the quintessential cytokine of T cell homeostasis. TGFβ signaling is required for the efficient differentiation and…
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Highly Cited
2004
Highly Cited
2004
Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells.
Daniel J Bernard
Molecular endocrinology
2004
The activins are pleiotropic members of the TGFbeta superfamily. Within the anterior pituitary gland, activins stimulate FSH…
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Highly Cited
2001
Highly Cited
2001
CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling.
A. Holmes
,
David J. Abraham
,
Sa Sa
,
Xia Shiwen
,
C. Black
,
Andrew Leask
The Journal of biological chemistry
2001
In normal adult fibroblasts, transforming growth factor-beta (TGFbeta) induces the expression of connective tissue growth factor…
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1999
1999
Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis.
Judith Heyer
,
Diana Escalante-Alcalde
,
+4 authors
Raju Kucherlapati
Proceedings of the National Academy of Sciences…
1999
SMAD2 is a member of the transforming growth factor beta and activin-signaling pathway. To examine the role of Smad2 in…
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Highly Cited
1996
Highly Cited
1996
MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma
Kolja Eppert
,
Stephen W. Scherer
,
+10 authors
Liliana Attisano
Cell
1996
5 inhibitory effects as tumor aggressiveness increases (re-1 associated with loss of TGF responsiveness in tumors and Liliana…
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Highly Cited
1996
Highly Cited
1996
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.
Kolja Eppert
,
Stefanie Scherer
,
+10 authors
Liliana Attisano
Cell
1996
The MAD-related (MADR) family of proteins are essential components in the signaling pathways of serine/threonine kinase receptors…
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