FAQ

SMAD2 gene

Known as: SMAD family member 2, SMAD2, MOTHERS AGAINST DECAPENTAPLEGIC, DROSOPHILA, HOMOLOG OF, 2 
This gene plays a role in signal transduction and repression of transcription.

Topic mentions per year

Topic mentions per year

1996-2018
0102019962018

Related topics

Related topics

9 relations
Cell Differentiation processCell Proliferation Regulatory ProcessColorectal CarcinomaHomo sapiens
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SMAD2 wt Allele

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
SMAD2 gene
Signal Transduction
Colorectal Carcinoma
Cell Differentiation process
dna binding
Homo sapiens

Papers overview

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Highly Cited
2013
Highly Cited
2013
SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer.
Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in the normal intestinal epithelium… (More)
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2012
2012
MiR-17-92 cluster regulates cell proliferation and collagen synthesis by targeting TGFB pathway in mouse palatal mesenchymal cells.
Elongation and elevation of palatal shelves, mainly caused by proliferation and extra-cellular matrix synthesis of palatal… (More)
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2011
2011
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma.
Glioblastoma multiforme (GBM) is the most common aggressive brain cancer with a median survival of approximately 1 year. In a… (More)
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Highly Cited
2010
Highly Cited
2010
MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-{beta}.
Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with important effects on processes such as fibrosis… (More)
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2010
2010
SMAD2 is essential for TGF beta-mediated Th17 cell generation.
TGFβ is the quintessential cytokine of T cell homeostasis. TGFβ signaling is required for the efficient differentiation and… (More)
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Highly Cited
2004
Highly Cited
2004
Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells.
The activins are pleiotropic members of the TGFbeta superfamily. Within the anterior pituitary gland, activins stimulate FSH… (More)
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Highly Cited
2001
Highly Cited
2001
CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling.
In normal adult fibroblasts, transforming growth factor-beta (TGFbeta) induces the expression of connective tissue growth factor… (More)
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1999
1999
Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis.
SMAD2 is a member of the transforming growth factor beta and activin-signaling pathway. To examine the role of Smad2 in… (More)
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Highly Cited
1996
Highly Cited
1996
MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma
5 inhibitory effects as tumor aggressiveness increases (re-1 associated with loss of TGF␤ responsiveness in tumors and Liliana… (More)
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Highly Cited
1996
Highly Cited
1996
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.
The MAD-related (MADR) family of proteins are essential components in the signaling pathways of serine/threonine kinase receptors… (More)
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