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SMAD2 gene

Known as: SMAD family member 2, SMAD2, MOTHERS AGAINST DECAPENTAPLEGIC, DROSOPHILA, HOMOLOG OF, 2 
This gene plays a role in signal transduction and repression of transcription.
National Institutes of Health

Related topics

Related topics

9 relations
Cell Differentiation processCell Proliferation Regulatory ProcessColorectal CarcinomaHomo sapiens
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SMAD2 wt Allele

Papers overview

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Highly Cited
2013
Highly Cited
2013
SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer.
Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in the normal intestinal epithelium… Expand
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Highly Cited
2010
Highly Cited
2010
Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.
Smad2 and Smad3 interact and mediate TGF-beta signaling. Although Smad3 promotes fibrosis, the role of Smad2 in fibrogenesis is… Expand
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Highly Cited
2009
Highly Cited
2009
Smad2 and 3 transcription factors control muscle mass in adulthood.
Loss of muscle mass occurs in a variety of diseases, including cancer, chronic heart failure, aquired immunodeficiency syndrome… Expand
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Review
2007
Review
2007
A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF‐β signaling
Transforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells, and insensitivity to this cytokine… Expand
Highly Cited
2002
Highly Cited
2002
Modulation of Smad2-mediated Signaling by Extracellular Signal-regulated Kinase*
Components of the transforming growth factor-β and mitogen-activated protein kinase pathways interact in controlling cell growth… Expand
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Highly Cited
2002
Highly Cited
2002
Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus.
The transcription factor Smad2 is released from cytoplasmic retention by TGFbeta receptor-mediated phosphorylation, accumulating… Expand
Highly Cited
1999
Highly Cited
1999
Ubiquitin-dependent degradation of TGF-β-activated Smad2
SMAD proteins are phosphorylated by transforming growth factor-β (TGF-β) receptors and translocate to the nucleus, where they… Expand
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Highly Cited
1996
Highly Cited
1996
MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling
MAD-related (MADR) proteins are essential intracellular components of TGFbeta signaling pathways and are regulated by… Expand
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Highly Cited
1996
Highly Cited
1996
MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma
The MAD-related (MADR) family of proteins are essential components in the signaling pathways of serine/threonine kinase receptors… Expand
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Highly Cited
1996
Highly Cited
1996
Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
THE TGF-β/activin/BMP superfamily of growth factors signals through heteromeric receptor complexes of type I and type II serine… Expand
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