SLX4 gene

Known as: KIAA1784, FANCP, KIAA1987 
This gene is involved in both DNA repair and the positive regulation of endonuclease activity.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
DNA interstrand crosslinks (ICLs), highly toxic lesions that covalently link the Watson and Crick strands of the double helix… (More)
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Highly Cited
2013
Highly Cited
2013
SLX4, the newly identified Fanconi anemia protein, FANCP, is implicated in repairing DNA damage induced by DNA interstrand cross… (More)
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Highly Cited
2011
Highly Cited
2011
Fanconi anemia is a rare recessive disorder characterized by genome instability, congenital malformations, progressive bone… (More)
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Highly Cited
2011
Highly Cited
2011
DNA interstrand crosslink repair requires several classes of proteins, including structure-specific endonucleases and Fanconi… (More)
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Highly Cited
2011
Highly Cited
2011
Interstrand cross-links (ICLs) block replication and transcription and thus are highly cytotoxic. In higher eukaryotes, ICLs… (More)
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Highly Cited
2011
Highly Cited
2011
The evolutionarily conserved SLX4 protein, a key regulator of nucleases, is critical for DNA damage response. SLX4 nuclease… (More)
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Highly Cited
2009
Highly Cited
2009
Structure-specific endonucleases mediate cleavage of DNA structures formed during repair of collapsed replication forks and… (More)
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Highly Cited
2009
Highly Cited
2009
Structure-specific endonucleases resolve DNA secondary structures generated during DNA repair and recombination. The yeast 5… (More)
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Highly Cited
2009
Highly Cited
2009
Budding yeast Slx4 interacts with the structure-specific endonuclease Slx1 to ensure completion of ribosomal DNA replication… (More)
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Highly Cited
2003
Highly Cited
2003
The RecQ DNA helicases human BLM and yeast Sgs1 interact with DNA topoisomerase III and are thought to act on stalled replication… (More)
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