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SLX4 gene

Known as: KIAA1784, FANCP, KIAA1987 
This gene is involved in both DNA repair and the positive regulation of endonuclease activity.
National Institutes of Health

Related topics

Related topics

3 relations
BTBD1 geneDNA RepairEnzyme Induction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Crystal structure and SUMO binding of Slx1-Slx4 complex
The SLX1-SLX4 complex is a structure-specific endonuclease that cleaves branched DNA structures and plays significant roles in… 
2015
2015
Termination of Replication Stress Signaling via Concerted Action of the Slx4 Scaffold and the PP4 Phosphatase
In response to replication stress, signaling mediated by DNA damage checkpoint kinases protects genome integrity. However… 
2015
2015
The Slx4-Dpb11 scaffold complex: coordinating the response to replication fork stalling in S-phase and the subsequent mitosis
Replication fork stalling at DNA lesions is a common problem during the process of DNA replication. One way to allow the bypass… 
2014
2014
Conditional Genetic Interactions of RTT107, SLX4, and HRQ1 Reveal Dynamic Networks upon DNA Damage in S. cerevisiae
The DNA damage response (DDR) is a dynamic process that is crucial for protecting the cell from challenges to genome integrity… 
2012
2012
Structure of C-terminal Tandem BRCT Repeats of Rtt107 Protein Reveals Critical Role in Interaction with Phosphorylated Histone H2A during DNA Damage Repair*
Background: Rtt107 can be recruited to chromatin during the DNA damage response. Results: Structures of C-terminal Rtt107 alone… 
2011
2011
Three Structure-Selective Endonucleases Are Essential in the Absence of BLM Helicase in Drosophila
DNA repair mechanisms in mitotically proliferating cells avoid generating crossovers, which can contribute to genome instability… 
2009
2009
Drosophila Hold'em Is Required for a Subset of Meiotic Crossovers and Interacts With the DNA Repair Endonuclease Complex Subunits MEI-9 and ERCC1
Three Drosophila proteins, ERCC1, MUS312, and MEI-9, function in a complex proposed to resolve double-Holliday-junction… 
2006
2006
Rad22Rad52-dependent repair of ribosomal DNA repeats cleaved by Slx1-Slx4 endonuclease.
Slx1 and Slx4 are subunits of a structure-specific DNA endonuclease that is found in Saccharomyces cerevisiae… 
2006
2006
Rad 22 Rad 52-dependent Repair of Ribosomal DNA Repeats Cleaved by Slx 1 – Slx 4 Endonuclease
Slx1 and Slx4 are subunits of a structure-specific DNA endonuclease that is found in Saccharomyces cerevisiae… 
Highly Cited
2005
Highly Cited
2005
Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage.
Members of the RecQ family of DNA helicases, mutated in several syndromes associated with cancer predisposition, are key… 
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