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SLCO1B3 wt Allele

Known as: SLC21A8, LST2, LST3 
Human SLCO1B3 wild-type allele is located in the vicinity of 12p12 and is approximately 279 kb in length. This allele, which encodes solute carrier… 
National Institutes of Health

Related topics

Related topics

6 relations
Homo sapiensIonophore activityLigand BindingMolecular Transport

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Special Section on Pediatric Drug Disposition and Pharmacokinetics Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver
Determining appropriate pharmacotherapy in young children can be challenging due to uncertainties in the development of drug… 
2015
2015
PBPK modeling of irbesartan: incorporation of hepatic uptake
Physiological based pharmacokinetic (PBPK) modeling is now commonly used in drug development to integrate human or animal… 
2013
2013
Prognostic value of organic anion transporting polypeptide 1B3 and copper transporter 1 expression in endometrial cancer patients treated with paclitaxel and carboplatin.
Paclitaxel and carboplatin (TC) chemotherapy is an effective and well-tolerated regimen against advanced endometrial cancer… 
2011
2011
Functional and Structural Relevance of Conserved Positively Charged Lysine Residues in Organic Anion Transporting Polypeptide 1B3
The human organic anion transporting polypeptide 1B3 (OATP1B3), located in the basolateral membrane of hepatocytes, mediates the… 
2011
2011
Hepatic expression of sodium-dependent vitamin C transporters: ontogeny, subtissular distribution and effect of chronic liver diseases
Ascorbic acid uptake is a key step in determining the overall bioactivity of this vitamin. Expression of Na-dependent vitamin C… 
2010
2010
The metabolism and disposition of a potent inhibitor of hepatitis C virus NS3/4A protease
Compound A ((1aR,5S,8S,10R,22aR)-5-tert-butyl-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-14-methoxy-3,6… 
2007
2007
Data-Based Mathematical Modeling of Vectorial Transport across Double-Transfected Polarized Cells
Vectorial transport of endogenous small molecules, toxins, and drugs across polarized epithelial cells contributes to their half… 
2006
2006
Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin
Rifampicin (rifampin) is a potent inducer of cytochrome P450 (CYP) 3A4. It was recently identified as a substrate of the… 
Highly Cited
2005
Highly Cited
2005
Vectorial Transport of the Peptide CCK-8 by Double-Transfected MDCKII Cells Stably Expressing the Organic Anion Transporter OATP1B3 (OATP8) and the Export Pump ABCC2
CCK-8 (l-aspartyl-l-tyrosyl-l-methionylglycyl-l-tryptophyl-l-methionyl-l-aspartyl-l-phenylalaninamide hydrogen sulfate ester), a… 
2003
2003
Influence of albumin binding on the substrate transport mediated by human hepatocyte transporters OATP2 and OATP8
Background: Despite their strong binding to albumin while circulating in blood, many organic anions, such as bilirubin and fatty… 
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