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SLCO1B1 wt Allele

Known as: OATP-C, OATP2, LST1 
Human SLCO1B1 wild-type allele is located in the vicinity of 12p12 and is approximately 109 kb in length. This allele, which encodes solute carrier… 
National Institutes of Health

Related topics

Related topics

5 relations
Homo sapiensIonophore activityLigand BindingMolecular Transport

Papers overview

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Highly Cited
2013
Highly Cited
2013
Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1
BackgroundOrganic anion transporting polypeptide (OATP) 1B1, OATP1B3, and OATP2B1 (encoded by SLCO1B1, SLCO1B3, SLCO2B1) mediate… 
Highly Cited
2008
Highly Cited
2008
Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin
Rosuvastatin is an HMG-CoA reductase inhibitor and one of the most hydrophilic among the commercially available statins. It is… 
Highly Cited
2006
Highly Cited
2006
INVOLVEMENT OF TRANSPORTERS IN THE HEPATIC UPTAKE AND BILIARY EXCRETION OF VALSARTAN, A SELECTIVE ANTAGONIST OF THE ANGIOTENSIN II AT1-RECEPTOR, IN HUMANS
Valsartan is a highly selective angiotensin II AT1-receptor antagonist for the treatment of hypertension. Valsartan is mainly… 
Highly Cited
2005
Highly Cited
2005
Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis
Mutations of the bile salt export pump (BSEP) or the multidrug resistance P‐glycoprotein 3 (MDR3) are linked to impaired bile… 
Highly Cited
2005
Highly Cited
2005
DIFFERENTIAL INTERACTION OF 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE INHIBITORS WITH ABCB1, ABCC2, AND OATP1B1
The present study examined the interaction of four 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (atorvastatin… 
Highly Cited
2004
Highly Cited
2004
Evidence for Inverse Effects of OATP‐C (SLC21A6) *5 and *1b Haplotypes on Pravastatin Kinetics
Highly Cited
2003
Highly Cited
2003
Polymorphisms of OATP‐C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics
Highly Cited
2003
Highly Cited
2003
Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.
Recent functional studies have suggested that, in addition to simple diffusion, carrier-mediated transport may play an important… 
Highly Cited
2001
Highly Cited
2001
Characterization of the Human OATP-C (SLC21A6) Gene Promoter and Regulation of Liver-specific OATP Genes by Hepatocyte Nuclear Factor 1α*
OATP-C (SLC21A6) is the predominant Na+-independent uptake system for bile salts and bilirubin of human liver and is expressed… 
Highly Cited
2000
Highly Cited
2000
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane.
We cloned and expressed a new organic anion transporting polypeptide (OATP), termed human OATP2, (OATP-C, LST-1; symbol SLC21A6… 
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