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SLCO1B1 wt Allele

Known as: OATP-C, OATP2, LST1 
Human SLCO1B1 wild-type allele is located in the vicinity of 12p12 and is approximately 109 kb in length. This allele, which encodes solute carrier… 
National Institutes of Health

Related topics

Related topics

5 relations
Homo sapiensIonophore activityLigand BindingMolecular Transport

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Dissecting the Contribution of OATP1B1 to Hepatic Uptake of Statins Using the OATP1B1 Selective Inhibitor Estropipate.
Identification of a selective inhibitor of organic anion transporting polypeptide (OATP) 1B1 is critical in order to determine… 
2016
2016
Inherited variation in OATP1B1 is associated with treatment outcome in acute myeloid leukemia
Using broad interrogation of clinically relevant drug absorption, distribution, metabolism, and excretion (ADME) genes on the… 
2015
2015
Generation of Bayesian prediction models for OATP-mediated drug-drug interactions based on inhibition screen of OATP1B1, OATP1B1∗15 and OATP1B3.
2015
2015
Association of CYP2D6*10, OATP1B1 A388G, and OATP1B1 T521C Polymorphisms and Overall Survival of Breast Cancer Patients after Tamoxifen Therapy
Background The global incidence of breast cancer is increasing, mainly due to the sharp rise in breast cancer incidence in Asia… 
2015
2015
PBPK modeling of irbesartan: incorporation of hepatic uptake
Physiological based pharmacokinetic (PBPK) modeling is now commonly used in drug development to integrate human or animal… 
2012
2012
Evaluation of Organic Anion-Transporting Polypeptide 1B1 and CYP3A4 Activities in Primary Human Hepatocytes and HepaRG Cells Cultured in a Dynamic Three-Dimensional Bioreactor System
The long-term stability of liver cell functions is a major challenge when studying hepatic drug transport, metabolism, and… 
Highly Cited
2011
Highly Cited
2011
Differential effect of genetic variants of Na+-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors
The purpose of this study was to investigate the effect of genetic variations in organic anion-transporting polypeptide 1B1… 
2010
2010
OATP1B1 388A>G polymorphism and pharmacokinetics of pitavastatin in Chinese healthy volunteers
Purpose:  To investigate the contribution of the most frequent single nucleotide polymorphism (SNPs) of the organic anion… 
2004
2004
Contribution of OATP 2 ( OATP 1 B 1 ) and OATP 8 ( OATP 1 B 3 ) to the Hepatic Uptake of Pitavastatin in Humans
Pitavastatin, a novel potent 3-hydroxymethylglutaryl-CoA reductase inhibitor, is selectively distributed to the liver in rats… 
2003
2003
Influence of albumin binding on the substrate transport mediated by human hepatocyte transporters OATP2 and OATP8
Background: Despite their strong binding to albumin while circulating in blood, many organic anions, such as bilirubin and fatty… 
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