SLC7A6 protein, human

Known as: Cationic Amino Acid Transporter, y+ System, LAT3 protein, human, Solute Carrier Family 7 Member 6 
Y+L amino acid transporter 2 (515 aa, ~57 kDa) is encoded by the human SLC7A6 gene. This protein is involved in dibasic amino acid transport.
National Institutes of Health

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Broader (1)

Amino Acid Transport Systems, Basic
Amino Acid TransporterCellular MembraneIntegral Membrane ProteinsIonophore activity
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Papers overview

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2015
2015
Arginine increases development of in vitro-produced porcine embryos and affects the protein arginine methyltransferase-dimethylarginine dimethylaminohydrolase-nitric oxide axis.
Culture systems promote development at rates lower than the in vivo environment. Here, we evaluated the embryo's transcriptome to… (More)
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2014
2014
Runx1t1 (Runt-Related Transcription Factor 1; Translocated to, 1) Epigenetically Regulates the Proliferation and Nitric Oxide Production of Microglia
BACKGROUND Microglia, the resident immune cells of the brain, undergo rapid proliferation and produce several proinflammatory… (More)
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2012
2012
Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/nitrosative stress and activation of matrix metalloproteinases.
Ammonia is responsible for cerebral edema associated with acute liver failure, but the role of the vasogenic mechanism has been a… (More)
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2009
2009
Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y+LAT2 roles
Since arginine metabolites, such as nitric oxide and polyamines, influence the expression of genes involved in erythroid… (More)
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2007
2007
Possible involvement of oxidative stress in piperonyl butoxide induced hepatocarcinogenesis in rats.
To clarify the possible mechanism of non-genotoxic hepatocarcinogenesis induced by piperonyl butoxide (PBO), male F344 rats were… (More)
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2007
2007
Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction.
BACKGROUND Endothelial dysfunction because of reduced nitric oxide bioavailability is a key feature of essential hypertension. We… (More)
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2005
2005
A y+LAT-1 mutant protein interferes with y+LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance
Lysinuric protein intolerance (LPI) is an inherited aminoaciduria caused by defective cationic amino acid (CAA) transport at the… (More)
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2003
2003
Characterization of cationic amino acid transporters and expression of endothelial nitric oxide synthase in human placental microvascular endothelial cells.
We investigated the expression and activity of arginine transporters and endothelial nitric oxide synthase (eNOS) in human… (More)
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2001
2001
Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.
Heterodimeric amino acid transporters are comprised of a type-II membrane protein named the heavy chain (4F2hc or rBAT) that may… (More)
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Highly Cited
2000
Highly Cited
2000
The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine.
The cationic amino acid arginine, due to its positive charge, is usually accumulated in the cytosol. Nevertheless, arginine has… (More)
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