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SLC7A6 protein, human

Known as: Cationic Amino Acid Transporter, y+ System, LAT3 protein, human, Solute Carrier Family 7 Member 6 
Y+L amino acid transporter 2 (515 aa, ~57 kDa) is encoded by the human SLC7A6 gene. This protein is involved in dibasic amino acid transport.
National Institutes of Health

Related topics

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13 relations

Broader (1)

Amino Acid Transport Systems, Basic
Amino Acid TransporterCellular MembraneIntegral Membrane ProteinsIonophore activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Effect of L-theanine on growth performance, intestinal development and health, and peptide and amino acid transporters expression of broilers.
BACKGROUND L-theanine has multiple beneficial biological activities. However, there is little information about the use of L… 
Review
2017
Review
2017
Roles of Glutamate and Glutamine Transport in Ammonia Neurotoxicity: State of the Art and Question Marks.
BACKGROUND Excessive accumulation of ammonia in the brain is a causative factor of an array of neurological manifestations of… 
2016
2016
The Glutamine Transporters and Their Role in the Glutamate/GABA-Glutamine Cycle.
Glutamine is a key amino acid in the CNS, playing an important role in the glutamate/GABA-glutamine cycle (GGC). In the GGC… 
Highly Cited
2012
Highly Cited
2012
Upregulation of the heteromeric y+LAT2 transporter contributes to ammonia-induced increase of arginine uptake in rat cerebral cortical astrocytes
Highly Cited
2012
Highly Cited
2012
Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/nitrosative stress and activation of matrix metalloproteinases
J. Neurochem. (2012) 121, 125–134. 
2011
2011
Hyperammonemia increases the expression and activity of the glutamine/arginine transporter y+LAT2 in rat cerebral cortex: Implications for the nitric oxide/cGMP pathway
Highly Cited
2007
Highly Cited
2007
Possible involvement of oxidative stress in piperonyl butoxide induced hepatocarcinogenesis in rats.
Highly Cited
2004
Highly Cited
2004
Characterization of cationic amino acid transporters and expression of endothelial nitric oxide synthase in human placental microvascular endothelial cells
We investigated the expression and activity of arginine transporters and endothelial nitric oxide synthase (eNOS) in human… 
Highly Cited
2001
Highly Cited
2001
Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.
Heterodimeric amino acid transporters are comprised of a type-II membrane protein named the heavy chain (4F2hc or rBAT) that may… 
Highly Cited
2000
Highly Cited
2000
The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine.
The cationic amino acid arginine, due to its positive charge, is usually accumulated in the cytosol. Nevertheless, arginine has… 
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