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SLC7A6 protein, human

Known as: Cationic Amino Acid Transporter, y+ System, LAT3 protein, human, Solute Carrier Family 7 Member 6 
Y+L amino acid transporter 2 (515 aa, ~57 kDa) is encoded by the human SLC7A6 gene. This protein is involved in dibasic amino acid transport.
National Institutes of Health

Related topics

Related topics

13 relations

Broader (1)

Amino Acid Transport Systems, Basic
Amino Acid TransporterCellular MembraneIntegral Membrane ProteinsIonophore activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
The Glutamine Transporters and Their Role in the Glutamate/GABA-Glutamine Cycle.
Glutamine is a key amino acid in the CNS, playing an important role in the glutamate/GABA-glutamine cycle (GGC). In the GGC… 
Review
2015
Review
2015
Maternal Factors Are Associated with the Expression of Placental Genes Involved in Amino Acid Metabolism and Transport
Introduction Maternal environment and lifestyle factors may modify placental function to match the mother’s capacity to support… 
Highly Cited
2013
Highly Cited
2013
Dietary arginine supplementation enhances intestinal expression of SLC7A7 and SLC7A1 and ameliorates growth depression in mycotoxin-challenged pigs
This study tested the hypothesis that dietary l-arginine supplementation confers beneficial effects on growing pigs fed a mold… 
Highly Cited
2012
Highly Cited
2012
Upregulation of the heteromeric y+LAT2 transporter contributes to ammonia-induced increase of arginine uptake in rat cerebral cortical astrocytes
Highly Cited
2012
Highly Cited
2012
Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/nitrosative stress and activation of matrix metalloproteinases
J. Neurochem. (2012) 121, 125–134. 
Highly Cited
2007
Highly Cited
2007
Possible involvement of oxidative stress in piperonyl butoxide induced hepatocarcinogenesis in rats.
Highly Cited
2007
Highly Cited
2007
Identification of a Novel Polymorphism in the 3′UTR of the l-Arginine Transporter Gene SLC7A1: Contribution to Hypertension and Endothelial Dysfunction
Background— Endothelial dysfunction because of reduced nitric oxide bioavailability is a key feature of essential hypertension… 
Highly Cited
2004
Highly Cited
2004
Characterization of cationic amino acid transporters and expression of endothelial nitric oxide synthase in human placental microvascular endothelial cells
We investigated the expression and activity of arginine transporters and endothelial nitric oxide synthase (eNOS) in human… 
Highly Cited
2001
Highly Cited
2001
Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.
Heterodimeric amino acid transporters are comprised of a type-II membrane protein named the heavy chain (4F2hc or rBAT) that may… 
Highly Cited
2000
Highly Cited
2000
The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine.
The cationic amino acid arginine, due to its positive charge, is usually accumulated in the cytosol. Nevertheless, arginine has… 
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