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Prediction model of potential hepatocarcinogenicity of rat hepatocarcinogens using a large-scale toxicogenomics database.
Mortality, Major Cause of Moribundity, and Spontaneous Tumors in CD-1 Mice
Mortality was significantly lowered in males and females born after 1980 in accordance with an abruptly decreased occurrence of systemic amyloidosis in these animals.
Chronic toxicity and carcinogenicity of methylmercury chloride in B6C3F1 mice.
Validation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing.
The rasH2 mouse appears to be a promising candidate as an animal model for development of a rapid carcinogenicity testing system and is able to detect various types of mutagenic carcinogens within 6 months.
Developmental toxicity of brominated flame retardants, tetrabromobisphenol A and 1,2,5,6,9,10-hexabromocyclododecane, in rat offspring after maternal exposure from mid-gestation through lactation.
Relationship between the development of hepato-renal toxicity and cadmium accumulation in rats given minimum to large amounts of cadmium chloride in the long-term: preliminary study
It is suggested that renal toxicity would not be induced by treatment with minimum amounts of CdCl2 for periods longer than 8 months, although accumulation ofCd might gradually progress.
Morphological evaluation of cyclophosphamide testicular toxicity in rats using quantitative morphometry of spermatogenic cycle stages.
- H. Matsui, K. Mitsumori, K. Yasuhara, H. Onodera, T. Shimo, M. Takahashi
- BiologyThe Journal of toxicological sciences
- 25 September 1995
It is indicated that testicular toxicity can be detected from Day 7 even after a single administration of Cp, and in group 2, testicularoxicity could also be clearly detected by this morphometric approach.
Chordomas in Fischer 344 Rats
- S. Stefanski, M. Elwell, K. Mitsumori, K. Yoshitomi, K. Dittrich, H. Giles
- Biology, MedicineVeterinary pathology
- 1 January 1988
Tissue sections and records of 56 rats with chordoma, identified in the National Toxicology Program's (NTP) data base of approximately 115,000 rats, were examined to determine morphological…
Subacute Toxicity Studies with Zinc Sulfate in Mice and Rats
This document summarizes the results of the company’s research and development activities in 2017 and outlines its plans for the future.
[A 90-day repeated dose oral toxicity study of magnesium chloride in F344 rats].
The no-observed-adverse-effect-level was estimated to be 0.5%, and 2.5% is considered to be appropriate as highest dose for a 2-year carcinogenicity study.