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SLC46A1 gene

Known as: PCFT, HEME CARRIER PROTEIN 1, MGC9564 
This gene plays a role in folate and antifolate transport.
National Institutes of Health

Related topics

Related topics

8 relations
Homo sapiensIonophore activityLigand BindingMolecular Transport

Papers overview

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2016
2016
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter…
Targeted antifolates with heteroatom replacements of the carbon vicinal to the phenyl ring in 1 by N (4), O (8), or S (9), or… 
2015
2015
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.
2-Amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine antifolate thiophene regioisomers of AGF94 (4) with a thienoyl side chain… 
2015
2015
The first Chinese case report of hereditary folate malabsorption with a novel mutation on SLC46A1
2014
2014
DNA methylation in the placenta and in cancerwith special reference to folate transporting genes
The oncogenic human papilloma viruses (HPVs) are associated with precancerous cervical lesions and development of cervical cancer… 
2014
2014
Orally Administered Melatonin Prevents Lipopolysaccharide-Induced Neural Tube Defects in Mice
Lipopolysaccharide (LPS) has been associated with adverse pregnant outcomes, including fetal demise, intra-uterine growth… 
2013
2013
Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.
The proton-coupled folate transporter (PCFT, SLC46A1) mediates folate transport across the apical brush-border membrane of the… 
2012
2012
Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity…
We previously reported the selective transport of classical 2-amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidines with a thienoyl… 
2010
2010
MUTATION OF THE PROTON-COUPLED FOLATE TRANSPORTER GENE (PCFT-SLC46A1) IN TURKISH SIBLINGS WITH HEREDITARY FOLATE MALABSORPTION
Hereditary folate malabsorption (HFM) is a rare autosomal recessive disorder characterized by systemic and central nervous system… 
2009
2009
Effect of Cannabinoids upon the Uptake of Folic Acid by BeWo Cells
Folic acid (FA) is an essential micronutrient that is particularly important during pregnancy for normal placental and fetal… 
Highly Cited
2005
Highly Cited
2005
Gene expression analysis of the mechanism of inhibition of Desulfovibrio vulgaris Hildenborough by nitrate-reducing, sulfide-oxidizing bacteria.
Sulfate-reducing bacteria (SRB) are inhibited by nitrate-reducing, sulfide-oxidizing bacteria (NR-SOB) in the presence of nitrate… 
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