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SLC46A1 gene

Known as: PCFT, HEME CARRIER PROTEIN 1, MGC9564 
This gene plays a role in folate and antifolate transport.
National Institutes of Health

Related topics

Related topics

8 relations
Homo sapiensIonophore activityLigand BindingMolecular Transport

Papers overview

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2016
2016
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter…
Targeted antifolates with heteroatom replacements of the carbon vicinal to the phenyl ring in 1 by N (4), O (8), or S (9), or… 
2014
2014
DNA methylation in the placenta and in cancerwith special reference to folate transporting genes
The oncogenic human papilloma viruses (HPVs) are associated with precancerous cervical lesions and development of cervical cancer… 
2014
2014
Orally Administered Melatonin Prevents Lipopolysaccharide-Induced Neural Tube Defects in Mice
Lipopolysaccharide (LPS) has been associated with adverse pregnant outcomes, including fetal demise, intra-uterine growth… 
2013
2013
Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.
The proton-coupled folate transporter (PCFT, SLC46A1) mediates folate transport across the apical brush-border membrane of the… 
2012
2012
Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity…
We previously reported the selective transport of classical 2-amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidines with a thienoyl… 
2012
2012
Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).
The proton-coupled folate transporter (PCFT) mediates intestinal folate absorption, and loss-of-function mutations in this gene… 
2012
2012
Functional Loss of the Reduced Folate Carrier Enhances the Antitumor Activities of Novel Antifolates with Selective Uptake by the Proton-Coupled Folate Transporter
Uptake of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with four or three bridge carbons [compound 1 (C1) and… 
2010
2010
MUTATION OF THE PROTON-COUPLED FOLATE TRANSPORTER GENE (PCFT-SLC46A1) IN TURKISH SIBLINGS WITH HEREDITARY FOLATE MALABSORPTION
Hereditary folate malabsorption (HFM) is a rare autosomal recessive disorder characterized by systemic and central nervous system… 
2009
2009
Effect of Cannabinoids upon the Uptake of Folic Acid by BeWo Cells
Folic acid (FA) is an essential micronutrient that is particularly important during pregnancy for normal placental and fetal… 
2009
2009
Hereditary folate malabsorption: a positively charged amino acid at position 113 of the proton-coupled folate transporter (PCFT/SLC46A1) is required for folic acid binding.
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