SLC46A1 gene

Known as: PCFT, HEME CARRIER PROTEIN 1, MGC9564 
This gene plays a role in folate and antifolate transport.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2017
0102019952017

Related topics

Related topics

8 relations
Homo sapiensIonophore activityLigand BindingMolecular Transport
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Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
SLC46A1 gene
Ligand Binding
Transmembrane Transport
Homo sapiens
Molecular Transport
folic acid metabolism

Papers overview

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2010
2010
The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1.
Folates are essential vitamins that play a key role as one-carbon donors in a spectrum of biosynthetic pathways including RNA and… (More)
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2009
2009
Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice.
Genetic disorders of homocysteine (Hcy) or folate metabolism or high-methionine diets elevate plasma Hcy and its atherogenic… (More)
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2008
2008
PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells.
The proton-coupled folate transporter (PCFT/SLC46A1) displays optimal and prominent folate and antifolate transport activity at… (More)
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2008
2008
Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations.
BACKGROUND Folate is an essential nutrient that supports nucleotide synthesis and biological methylation reactions. Diminished… (More)
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2008
2008
N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT).
The human proton-coupled folate transporter (HsPCFT, SLC46A1) mediates intestinal absorption of folates and transport of folates… (More)
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2008
2008
Characterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model.
Reduced derivatives of folic acid (folates) play a critical role in the development, function and repair of the CNS. However, the… (More)
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2008
2008
Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model.
Proton-coupled folate transporter/heme carrier protein 1 (PCFT/HCP1) has recently been identified as a transporter that mediates… (More)
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2007
2007
Effect of folate oversupplementation on folate uptake by human intestinal and renal epithelial cells.
BACKGROUND Folic acid [corrected] plays an essential role in cellular metabolism. Its deficiency can lead to neural tube defects… (More)
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2007
2007
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.
This laboratory recently identified a human gene that encodes a novel folate transporter [Homo sapiens proton-coupled folate… (More)
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2007
2007
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.
The functional characteristics of human proton coupled folate transporter (hPCFT)/heme carrier protein (HCP) 1 were investigated… (More)
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