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SLC46A1 gene
Known as:
PCFT
, HEME CARRIER PROTEIN 1
, MGC9564
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This gene plays a role in folate and antifolate transport.
National Institutes of Health
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Related topics
Related topics
8 relations
Homo sapiens
Ionophore activity
Ligand Binding
Molecular Transport
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter…
Lalit K. Golani
,
Adrianne Wallace-Povirk
,
+17 authors
A. Gangjee
Journal of Medicinal Chemistry
2016
Corpus ID: 13349354
Targeted antifolates with heteroatom replacements of the carbon vicinal to the phenyl ring in 1 by N (4), O (8), or S (9), or…
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2014
2014
DNA methylation in the placenta and in cancerwith special reference to folate transporting genes
Sanja A. Farkas
2014
Corpus ID: 51827588
The oncogenic human papilloma viruses (HPVs) are associated with precancerous cervical lesions and development of cervical cancer…
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2014
2014
Orally Administered Melatonin Prevents Lipopolysaccharide-Induced Neural Tube Defects in Mice
Lin Fu
,
Zhen Yu
,
+5 authors
De-xiang Xu
PLoS ONE
2014
Corpus ID: 8728855
Lipopolysaccharide (LPS) has been associated with adverse pregnant outcomes, including fetal demise, intra-uterine growth…
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2013
2013
Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.
Daniel Sanghoon Shin
,
R. Zhao
,
A. Fiser
,
I. Goldman
American Journal of Physiology - Cell Physiology
2013
Corpus ID: 10396102
The proton-coupled folate transporter (PCFT, SLC46A1) mediates folate transport across the apical brush-border membrane of the…
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2012
2012
Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity…
Lei Wang
,
Christina Cherian
,
+4 authors
A. Gangjee
Journal of Medicinal Chemistry
2012
Corpus ID: 207228688
We previously reported the selective transport of classical 2-amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidines with a thienoyl…
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2012
2012
Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).
R. Zhao
,
D. Shin
,
A. Fiser
,
I. Goldman
American Journal of Physiology - Cell Physiology
2012
Corpus ID: 43803437
The proton-coupled folate transporter (PCFT) mediates intestinal folate absorption, and loss-of-function mutations in this gene…
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2012
2012
Functional Loss of the Reduced Folate Carrier Enhances the Antitumor Activities of Novel Antifolates with Selective Uptake by the Proton-Coupled Folate Transporter
S. Desmoulin
,
Lei Wang
,
+7 authors
L. Matherly
Molecular Pharmacology
2012
Corpus ID: 5952293
Uptake of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with four or three bridge carbons [compound 1 (C1) and…
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2010
2010
MUTATION OF THE PROTON-COUPLED FOLATE TRANSPORTER GENE (PCFT-SLC46A1) IN TURKISH SIBLINGS WITH HEREDITARY FOLATE MALABSORPTION
B. Atabay
,
M. Turker
,
E. Ozer
,
K. Mahadeo
,
N. Diop-Bove
,
I. Goldman
Pediatric Hematology & Oncology
2010
Corpus ID: 10856833
Hereditary folate malabsorption (HFM) is a rare autosomal recessive disorder characterized by systemic and central nervous system…
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2009
2009
Effect of Cannabinoids upon the Uptake of Folic Acid by BeWo Cells
J. Araújo
,
P. Gonçalves
,
F. Martel
Pharmacology
2009
Corpus ID: 38869998
Folic acid (FA) is an essential micronutrient that is particularly important during pregnancy for normal placental and fetal…
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2009
2009
Hereditary folate malabsorption: a positively charged amino acid at position 113 of the proton-coupled folate transporter (PCFT/SLC46A1) is required for folic acid binding.
Inbal Lasry
,
B. Berman
,
F. Glaser
,
G. Jansen
,
Y. Assaraf
Biochemical and Biophysical Research…
2009
Corpus ID: 25584607
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