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SLC31A1 protein, human

Known as: Copper Transporter 1, solute carrier family 31 (copper transporters), member 1 protein, human, High Affinity Copper Uptake Protein 1 
High affinity copper uptake protein 1 (190 aa, ~21 kDa) is encoded by the human SLC31A1 gene. This protein plays a role in copper ion transport.
National Institutes of Health

Related topics

Related topics

13 relations

Broader (2)

Cation Transport Proteinscopper transporter 1
Cellular MembraneIntegral Membrane ProteinsIonophore activityLigand Binding

Papers overview

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Highly Cited
2015
Highly Cited
2015
Overexpression of the RNA-binding proteins Lin28B and IGF2BP3 (IMP3) is associated with chemoresistance and poor disease outcome in ovarian cancer
Background:RNA-binding proteins have an important role in messenger RNA (mRNA) regulation during tumour development and… 
Highly Cited
2013
Highly Cited
2013
A Re-Evaluation of the Role of hCTR1, the Human High-Affinity Copper Transporter, in Platinum-Drug Entry into Human Cells
Cisplatin (cDDP) is an anticancer drug used in a number of malignancies, including testicular, ovarian, cervical, bladder, lung… 
Highly Cited
2011
Highly Cited
2011
Acquisition of dietary copper: a role for anion transporters in intestinal apical copper uptake.
Copper is an essential micronutrient in humans and is required for a wide range of physiological processes, including… 
Highly Cited
2010
Highly Cited
2010
Ctr1 transports silver into mammalian cells.
Highly Cited
2010
Highly Cited
2010
The role of the N-terminus of mammalian copper transporter 1 in the cellular accumulation of cisplatin.
Highly Cited
2007
Highly Cited
2007
O-Linked Glycosylation at Threonine 27 Protects the Copper Transporter hCTR1 from Proteolytic Cleavage in Mammalian Cells*
The major human copper uptake protein, hCTR1, has 190 amino acids and a predicted mass of 21 kDa. hCTR1 antibodies recognize… 
Review
2007
Review
2007
A structural perspective on copper uptake in eukaryotes
Over a decade ago, genetic studies identified a family of small integral membrane proteins, commonly referred to as copper… 
Highly Cited
2004
Highly Cited
2004
The Copper Influx Transporter Human Copper Transport Protein 1 Regulates the Uptake of Cisplatin in Human Ovarian Carcinoma Cells
Cells selected for resistance to cisplatin are often cross-resistant to copper and vice versa, and the major copper influx… 
Highly Cited
2004
Highly Cited
2004
Cisplatin Rapidly Down-regulates Its Own Influx Transporter hCTR1 in Cultured Human Ovarian Carcinoma Cells
Purpose: Cisplatin (DDP)-resistant cells commonly exhibit reduced drug accumulation. Previous studies have shown that the major… 
Highly Cited
2003
Highly Cited
2003
The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itself.
We have used indirect immunofluorescense studies and glycosylation-site insertion and deletion mapping to characterize the… 
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