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SLC16A3 wt Allele

Known as: MCT-3, MCT-4, Solute Carrier Family 16 (Monocarboxylate Transporter), Member 3 wt Allele 
Human SLC16A3 wild-type allele is located in the vicinity of 17q25 and is approximately 33 kb in length. This allele, which encodes monocarboxylate… 
National Institutes of Health

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6 relations
17q25Homo sapiensIonophore activityLigand Binding

Papers overview

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2020
2020
Comparison of neuronal death and expression of TNF-α and MCT4 in the gerbil hippocampal CA1 region induced by ischemia/reperfusion under hyperthermia to those under normothermia
Monocarboxylate transporter 4 (MCT4) is a high-capacity lactate transporter in cells and the alteration in MCT4 expression harms… 
2016
2016
Prostate cancer: MCT4 is a novel target for prostate cancer
MCT4 represent a potential novel approach for the treatment of castration-resistant prostate cancer (CRPC), say researchers. New… 
2015
2015
Involvement of Histidine Residue His382 in pH Regulation of MCT4 Activity
Monocarboxylate transporter 4 (MCT4) is a pH-dependent bi-directional lactate transporter. Transport of lactate via MCT4 is… 
2015
2015
Monocarboxylate transporter 4 plays a significant role in the neuroprotective mechanism of ischemic preconditioning in transient cerebral ischemia
Monocarboxylate transporters (MCTs), which carry monocarboxylates such as lactate across biological membranes, have been… 
2014
2014
Endurance Training Alters Skeletal Muscle MCT Contents in T2DM Men
Abstract Patients suffering from type 2 diabetes mellitus (T2DM) often exhibit chronic elevated lactate levels which can promote… 
2014
2014
A Novel Agent with Histone Deacetylase Inhibitory Activity Attenuates Neointimal Hyperplasia
PurposeNeointimal hyperplasia (NIH), a pathophysiological event identified in bypass graft and stent re-stenosis, is… 
Highly Cited
2013
Highly Cited
2013
Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment
Here, we developed a model system to evaluate the metabolic effects of oncogene(s) on the host microenvironment. A matched set of… 
2013
2013
MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer
Normal oral mucosa is highly organized and contains three morphologically distinct compartments. These include: (1) an Here, we… 
2011
2011
The anti-leukemic effect and molecular mechanisms of novel hydroxamate and benzamide histone deacetylase inhibitors with 5-aza-cytidine.
Histone deacetylase inhibitors (HDACi) demonstrate considerable in vitro and in vivo activity and clinical efficacy in the… 
2006
2006
MCT‐4, A511/basigin and EF5 expression patterns during early chick cardiomyogenesis indicate cardiac cell differentiation occurs in a hypoxic environment
We have identified the presence of the hypoxia marker EF5 in the stage 4/5 chick heart fields. This suggests that cardiac cell… 
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