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SK&F 86002

Known as: SKF 86002, SKF86002 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
C-Fos Regulation by the MAPK and PKC Pathways in Intervertebral Disc Cells
Background The gene encoding c-fos is an important factor in the pathogenesis of joint disease in patients with osteoarthritis… 
Highly Cited
2008
Highly Cited
2008
Critical role of p38 mitogen-activated protein kinase signaling in septic lung injury*
Objective: Leukocyte-mediated tissue damage is a key feature in septic lung injury, although the signaling mechanisms behind… 
Highly Cited
2007
Highly Cited
2007
Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase Activate Bax to Induce Mitochondrial Cytochrome c Release and Apoptosis in Response to Malonate
Malonate, an inhibitor of mitochondrial complex II, is a widely used toxin to study neurodegeneration in Huntington's disease and… 
Highly Cited
2006
Highly Cited
2006
Protection of glioblastoma cells from cisplatin cytotoxicity via protein kinase Cι-mediated attenuation of p38 MAP kinase signaling
Glioblastoma multiforme is an aggressive form of brain cancer that responds poorly to chemotherapy and is generally incurable… 
Highly Cited
2003
Highly Cited
2003
Role of the p38 MAPK pathway in cisplatin-based therapy
p38 MAPK has been implicated in the response to cancer therapy. To determine whether the activation of p38 MAPK could be specific… 
2003
2003
P38 MAPK: critical molecule in thrombin-induced NF-κB-dependent leukocyte recruitment
Thrombin-stimulated endothelium synthesizes numerous adhesion molecules to recruit leukocytes; however, it is unknown which… 
Highly Cited
2001
Highly Cited
2001
Role of p38 Mitogen-Activated Protein Kinase in Chemokine-Induced Emigration and Chemotaxis In Vivo1
It has been proposed that L-selectin engagement with ligand activates p38 mitogen-activated protein kinase (MAPK) and can impact… 
Highly Cited
2000
Highly Cited
2000
Differential Regulation of Prostaglandin E2 and Thromboxane A2 Production in Human Monocytes: Implications for the Use of Cyclooxygenase Inhibitors1
There is an autocrine relationship between eicosanoid and cytokine synthesis, with the ratio of prostaglandin E2 (PGE2… 
Highly Cited
1995
Highly Cited
1995
Inhibition of interleukin-1 beta production by SKF86002: evidence of two sites of in vitro activity and of a time and system dependence.
Cytokine-suppressing anti-inflammatory drugs (CSAIDs) are reported to inhibit production of proinflammatory cytokines such as… 
1994
1994
Cytokine suppressive anti-inflammatory compounds inhibit bone resorption in vitro.
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