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Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
PROSTAGLANDINS have wide-ranging effects in the body and are thought to be important mediators of inflammation. Cyclooxygen-ase (COX) plays a key regulatory role in prostaglandin synthesis, andExpand
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Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis.
The potential for interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) to induce neutrophil and mononuclear phagocyte accumulation in the lungs of patients with pulmonary sarcoidosis andExpand
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Interferon gamma receptor deficient mice are resistant to endotoxic shock
Antibody neutralization studies have established interferon gamma (IFN- gamma) as a critical mediator of endotoxic shock. The advent of IFN- gamma receptor negative (IFN gamma R-/-) mutant mice hasExpand
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Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-α double-deficient mice
To investigate the roles of tumor necrosis factor (TNF) and lymphotoxin (LT)-alpha in the development and function of the immune system, the Tnf and Ltalpha genes were simultaneously inactivated inExpand
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IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.
The ubiquitous transcription factor NF-kappaB is an essential component in signal transduction pathways, in inflammation, and in the immune response. NF-kappaB is maintained in an inactive state inExpand
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The Toxicology of Interleukin-12: A Review
Recombinant murine interleukin (IL)-12 (rmIL-12) exhibits antitumor, antiviral, and antimicrobial activities and can modify allergic inflammatory reactions in animal models. Recombinant human IL-12Expand
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The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo
Interleukin (IL)-12 synergizes with other cytokines to stimulate the proliferation and differentiation of early hematopoietic progenitors in vitro. However, in vivo administration of IL-12 decreasesExpand
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Reversible drug-induced oxyntic atrophy in rats.
BACKGROUND & AIMS Oxyntic atrophy is the hallmark of chronic gastritis. Many studies have sought to develop animal models for oxyntic atrophy, but none of them are reversible. We now report that ratsExpand
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Inhibition of kinases impairs neutrophil activation and killing of Staphylococcus aureus.
Intracellular phosphorylations polymorphonuclear neutrophils are mediated by kinases, including mitogen activated-protein (MAP) kinases and phosphatidylinositol 3-kinase. In the present study weExpand
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Clinical Pathology of the Rat
Publisher Summary This chapter provides a basis for how clinical pathology parameters are used to correctly diagnose toxicity and naturally occurring disease in the rat. Hematology data are generallyExpand
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