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SK&F 102922

Known as: SK&F-102922, SKF 102922 
National Institutes of Health

Papers overview

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1992
1992
Metabolism of the leukotriene receptor antagonist 5-(2-(8-phenyloctyl)phenyl)-4,6-dithianonanedioic acid (SK&F 102922) in the guinea pig. Rearrangement of the acyl glucuronide.
A primary route of inactivation of leukotrienes and their receptor antagonists (LTRA) is metabolism by omega oxidation. SK&F… 
1991
1991
Direct vasoconstriction evoked by A1-adenosine receptor stimulation in the cutaneous microcirculation.
To determine whether the vasoconstriction evoked by A1-adenosine receptor stimulation in the skin circulation caused the release… 
1990
1990
Leukotriene D4 excitation of rabbit distal colon arises in the region of the muscularis mucosae.
We previously have demonstrated in vivo that intra-arterial administration of leukotriene D4 (LTD4) causes increased myoelectric… 
1989
1989
Arteriolar oxygen reactivity is inhibited by leukotriene antagonists.
Experiments were performed to test the hypothesis that the arteriolar constriction produced by elevated oxygen tensions in the… 
1988
1988
Identification and transmembrane signaling of leukotriene D4 receptors in human mesangial cells.
Although peptidoleukotriene (LTC4, LTD4) receptors have been characterized by radioligand binding studies, pathways of… 
1988
1988
Characterization of the conjunctival vasopermeability response to leukotrienes and their involvement in immediate hypersensitivity.
The microvascular permeability response of the guinea pig conjunctiva to sulfidopeptide leukotrienes (LTs) was quantified as… 
1987
1987
Leukotriene-induced hydrolysis of inositol lipids in guinea pig lung: mechanism of signal transduction for leukotriene-D4 receptors.
Addition of leukotriene D4 (LTD4) to [3H]myo-inositol-labeled guinea pig lung induced rapid breakdown of inositol lipids… 
1987
1987
Enhancement of leukotriene D4-induced contraction of guinea-pig isolated trachea by platelet activating factor.
1987
1987
Inhibition of leukotriene D4-induced coronary vasoconstriction by leukotriene antagonists in the anesthetized dog.
Anesthetized open-chest dogs were instrumented for the measurement of left circumflex coronary artery (LCX) blood flow and aortic… 
1986
1986
Leukotriene D4 receptor-mediated synthesis and release of arachidonic acid metabolites in guinea pig lung: induction of thromboxane and prostacyclin biosynthesis by leukotriene D4.
The effects of the peptidoleukotrienes C4 (LTC4), D4 (LTD4), E4 (LTE4) and a series agonists and antagonists on arachidonic acid… 
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