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Current two-dimensional electrophoresis technology for proteomics.
Two-dimensional gel electrophoresis (2-DE) with immobilized pH gradients (IPGs) combined with protein identification by mass spectrometry (MS) is currently the workhorse for proteomics. In spite of… Expand
A modified silver staining protocol for visualization of proteins compatible with matrix‐assisted laser desorption/ionization and electrospray ionization‐ mass spectrometry
The growing availability of genomic sequence information, together with improvements in analytical methodology, have enabled high throughput, high sensitivity protein identification. Silver staining… Expand
Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: Evidence for disease-associated changes.
- C. Beasley, K. Pennington, Aine Behan, R. Wait, M. Dunn, D. Cotter
- Biology, Medicine
- 1 June 2006
Abnormalities of the anterior cingulate cortex have previously been described in schizophrenia, major depressive disorder and bipolar disorder. In this study 2-DE was performed followed by mass… Expand
Biphasic activation of p21ras by endothelin‐1 sequentially activates the ERK cascade and phosphatidylinositol 3‐kinase
Endothelin‐1 (ET‐1) induces cell proliferation and differentiation through multiple G‐protein‐linked signaling systems, including p21ras activation. Whereas p21ras activation and desensitization by… Expand
2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease.
The mechanisms underlying white matter changes in psychiatric disease are not known. We aimed to characterise the differential protein expression in deep white matter from the dorsolateral prefrontal… Expand
Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein…
- ÁT Behan, C. Byrne, M. Dunn, G. Cagney, D. Cotter
- Psychology, Medicine
- Molecular Psychiatry
- 1 June 2009
The dorsolateral prefrontal cortex (dlpfc) is strongly implicated in the pathogenesis of schizophrenia (SCZ) and bipolar disorder (BPD) and, within this region, abnormalities in glutamatergic… Expand
Physiology of the mesangial cell.
Ce travail resume et discute de nombreuses investigations realisees dans le but d'etudier la structure, la physiologie et le role des cellules mesengiales
Induction of Mitogen-activated Protein Kinase Phosphatase 1 by the Stress-activated Protein Kinase Signaling Pathway but Not by Extracellular Signal-regulated Kinase in Fibroblasts (*)
- D. Bokemeyer, A. Sorokin, M. Yan, N. Ahn, D. Templeton, M. Dunn
- Biology, Medicine
- The Journal of Biological Chemistry
- 12 January 1996
The intracellular mechanisms involved in the activation of extracellular signal-regulated kinase (ERK) are relatively well understood. However, the intracellular signaling pathways which regulate the… Expand
Proteomics: new perspectives, new biomedical opportunities
Proteomics-based approaches, which examine the expressed proteins of a tissue or cell type, complement the genome initiatives and are increasingly being used to address biomedical questions. Proteins… Expand