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SJA 6017

Known as: SJA-6017, SJA6017 
National Institutes of Health

Papers overview

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2006
2006
Retinal penetration of calpain inhibitors in rats after oral administration.
Calpain-mediated proteolysis has been involved in neuronal cell death of retinal neurological degeneration. An aldehyde-based… 
2006
2006
Exploration of orally available calpain inhibitors 2: peptidyl hemiacetal derivatives.
We previously reported a potent calpain inhibitor 1 (SJA6017, N-(4-fluorophenyl)-l-valyl-l-leucinal), which displayed relatively… 
2006
2006
Exploration of orally available calpain inhibitors. Part 3: Dipeptidyl alpha-ketoamide derivatives containing pyridine moiety.
2005
2005
Calpain may contribute to hereditary cataract formation in sheep.
PURPOSE To determine the involvement of calpain in ovine cataractogenesis by measuring calcium, calpain activity, proteolysis… 
2004
2004
The in vitro retardation of porcine cataractogenesis by the calpain inhibitor, SJA6017
Calpain inhibitors show the potential to serve as non-surgical alternatives in treating diabetic cataract and other types of… 
2003
2003
Exploration of cornea permeable calpain inhibitors as anticataract agents.
2001
2001
Calpain inhibitor, SJA6017, reduces the rate of formation of selenite cataract in rats
Purposes. 1) To measure the amount of calpain inhibitor SJA6017 taken up by lenses of young rats after administration; and 2) To… 
Highly Cited
2000
Highly Cited
2000
Involvement of calpain isoforms in ischemia-reperfusion injury in rat retina
Purpose. Much evidence has accumulated suggesting that activation of calpain causes neuronal cell death in ischemic brain… 
1999
1999
Decreased sensitivity of lens-specific calpain Lp82 to calpastatin inhibitor.
The purpose of the present investigation was to test three calpain inhibitors (recombinant calpastatin domain I, E64, and SJA6017… 
Highly Cited
1997
Highly Cited
1997
SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: amelioration of cataract in cultured rat lenses.
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