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In Vitro Pharmacological Characterization of Novel Isoxazolopyridone Derivatives as Allosteric Metabotropic Glutamate Receptor 7 Antagonists
- G. Suzuki, Naohiro Tsukamoto, H. Ohta
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 October 2007
MMPIP is the first allosteric mGluR7-selective antagonist that could potentially be useful as a pharmacological tool for elucidating the roles of mGLUR7 on central nervous system functions.
Two kynurenine aminotransferases in human brain
Identification and quantification of kynurenic acid in human brain tissue
Exploration of orally available calpain inhibitors: peptidyl alpha-ketoamides containing an amphiphile at P3 site.
Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.
Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor.
Novel N-arylsulfonyldipeptidyl aldehyde derivatives prepared by DMSO oxidation from the corresponding dipeptide alcohol, and their potencies as calpain inhibitors were evaluated in vitro, exhibiting a relatively safe profile.
Catalytic enantioselective allylation of ketimines by using palladium pincer complexes with chiral bis(imidazoline)s.
Using chiral 1,3-bis(imidazolin-2-yl)benzene (Phebim)-Pd(II) complexes afforded products with good enantioselectivity and can be converted to homoallylic amines and a spirocyclic amine without the loss of enantiopurity.
Exploration of cornea permeable calpain inhibitors as anticataract agents.
Novel 6-hydroxy-3-morpholinones as cornea permeable calpain inhibitors.