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SHR, Rat Strain

Known as: SHR 
SHR: rats develop hypertension spontaneously without exception at the age of 7-15 weeks. There is a systolic blood pressure plateau of about 200 mmHg… 
National Institutes of Health

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Related topics

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Clinical Data Interchange Standards Consortium Terminology

Papers overview

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Highly Cited
2007
Highly Cited
2007
An Evolutionarily Conserved Mechanism Delimiting SHR Movement Defines a Single Layer of Endodermis in Plants
Intercellular protein movement plays a critical role in animal and plant development. SHORTROOT (SHR) is a moving transcription… 
Highly Cited
2002
Highly Cited
2002
Expression and Cellular Localization of Classic NADPH Oxidase Subunits in the Spontaneously Hypertensive Rat Kidney
Phagocytes generate superoxide anion (O2−) by a classic, 5-component NADPH oxidase. O2− contributes to hypertension in… 
Highly Cited
2000
Highly Cited
2000
Soluble Epoxide Hydrolase Regulates Hydrolysis of Vasoactive Epoxyeicosatrienoic Acids
The cytochrome P450-derived epoxyeicosatrienoic acids (EETs) have potent effects on renal vascular reactivity and tubular sodium… 
Highly Cited
2000
Highly Cited
2000
Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats.
This study was designed to test the hypothesis that stimulation of nicotinamide adenine dinucleotide/nicotinamide adenine… 
Highly Cited
1998
Highly Cited
1998
Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide.
Superoxide radical (O2-) is increased in the vessel wall of spontaneously hypertensive rats (SHR) where its blockade potentiates… 
Highly Cited
1995
Highly Cited
1995
Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hypertensive rat.
BACKGROUND Fibrosis is commonly found in association with cardiac hypertrophy and failure, but the relation of the connective… 
Highly Cited
1995
Highly Cited
1995
In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats. Hydroethidine microfluorography.
The factors that predispose to the accelerated organ injury that accompanies the hypertensive syndrome have remained speculative… 
Highly Cited
1987
Highly Cited
1987
Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats.
Spontaneously hypertensive rats (SHR) and normotensive control, Wistar/Kyoto (WKY) rats through two generations were fed a… 
Highly Cited
1983
Highly Cited
1983
Role of endothelium in dilator responses of spontaneously hypertensive rat arteries.
The possible role of endothelium in the vascular responses to vasodilator drugs was studied in relation to experimental… 
Highly Cited
1974
Highly Cited
1974
Blood pressure changes produced by kidney cross-transplantation between spontaneously hypertensive rats and normotensive rats.
1. From a single strain of Wistar rats two lines of normotensive rats (NR) and two lines of hypertensive rats (SHR) were… 
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