SHARPIN gene

Known as: SHANK-ASSOCIATED RH DOMAIN INTERACTOR, SHANK-Associated RH Domain Interactor Gene, SHANK-INTERACTING PROTEIN-LIKE 1 
This gene is involved in polyubiquitination.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
RIP1 (RIPK1) kinase is a key regulator of TNF-induced NF-κB activation, apoptosis, and necroptosis through its kinase and… (More)
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Highly Cited
2014
Highly Cited
2014
SHARPIN regulates immune signaling and contributes to full transcriptional activity and prevention of cell death in response to… (More)
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2014
2014
Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiquitin chains and is important… (More)
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Highly Cited
2012
Highly Cited
2012
The linear ubiquitin chain assembly complex (LUBAC) is a RING E3 ligase that regulates immune and inflammatory signalling… (More)
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Highly Cited
2011
Highly Cited
2011
SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when mutated in mice, results in immune system… (More)
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Highly Cited
2011
Highly Cited
2011
Cpdm (chronic proliferative dermatitis) mice develop chronic dermatitis and an immunodeficiency with increased serum IgM… (More)
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Highly Cited
2011
Highly Cited
2011
Members of the tumour necrosis factor (TNF) receptor superfamily have important functions in immunity and inflammation. Recently… (More)
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Highly Cited
2011
Highly Cited
2011
Regulated activation of integrins is critical for cell adhesion, motility and tissue homeostasis. Talin and kindlins activate β1… (More)
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2010
2010
In order to discover previously unidentified cancer-associated genes, we analyzed genome-wide differences in gene expression… (More)
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Highly Cited
2007
Highly Cited
2007
Homologues of the SHARPIN (SHANK-associated RH domain-interacting protein) gene have been identified in the human, rat and mouse… (More)
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