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SH2D1B protein, human

Known as: SH2 Domain-Containing Molecule EAT2, EWS/FLI1-Activated Transcript 2, SH2 domain containing 1B protein, human 
SH2 domain-containing protein 1B (132 aa, ~15 kDa) is encoded by the human SH2D1B gene. This protein plays a role in the regulation of receptor… 
National Institutes of Health

Related topics

Related topics

8 relations
NK Cell ActivationReceptor Activation ProcessSH2 DomainSH2D1B gene

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Papers overview

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2019
2019
ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans
2012
2012
Experimental validation of new drugs for calorie restriction from computational models
This work assesses a new bioinformatic tool, the Connectivity Map (Cmap), in predicting Calorie Restriction Mimetic (CRM… 
2012
2012
The chicken SLAM family
The signaling lymphocytic activation molecule (SLAM) family of receptors is critically involved in the immune regulation of… 
2011
2011
The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans.
Review
2011
Review
2011
Targeting HIV-1 innate immune responses therapeutically.
PURPOSE OF REVIEW The early stage of HIV-1 infection is when the virus is most vulnerable, and should therefore offer the best… 
2010
2010
C 57 BL / 6 Mouse CD 84-Dependent NK Cell Functions in the-2 B Are Positive Regulators of CD 244-and Cutting Edge : The Adapters EAT-2 A and
EWS/FLI1-activated transcript 2 (EAT-2)A and EAT-2B are single SH2-domain proteins, which bind to phosphorylated tyrosines of… 
Highly Cited
2009
Highly Cited
2009
Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
CRACC is a self-associating member of the signaling lymphocytic activation molecule family that is expressed on cells of the… 
Highly Cited
2006
Highly Cited
2006
Molecular Analysis of NTB-A Signaling: A Role for EAT-2 in NTB-A-Mediated Activation of Human NK Cells1
Engagement of NTB-A on human NK cells by homophilic interaction with NTB-A-expressing target cells can trigger NK cell… 
Highly Cited
2005
Highly Cited
2005
Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor
EAT-2 is an adaptor expressed in innate immune cells, including natural killer (NK) cells. It is closely related to the adaptor… 
2002
2002
The SAP Family: A New Class of Adaptor-Like Molecules That Regulates Immune Cell Functions
EAT-2 is a member of a newly described adaptor-like protein family consisting, at the moment, of EAT-2 and the signaling… 
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