Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

@article{Roncagalli2005NegativeRO,
  title={Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor},
  author={Romain Roncagalli and James E R Taylor and Shaohua Zhang and Xiaochu Shi and Riyan Chen and Mario-Ernesto Cruz-Munoz and Luo Yin and Sylvain Latour and Andr{\'e} Veillette},
  journal={Nature Immunology},
  year={2005},
  volume={6},
  pages={1002-1010}
}
EAT-2 is an adaptor expressed in innate immune cells, including natural killer (NK) cells. It is closely related to the adaptor SAP, which regulates signaling lymphocyte activation molecule (SLAM)–related receptors by recruiting the kinase FynT to the receptors. Here we have studied the function of EAT-2 in NK cells by creating mice lacking or overexpressing EAT-2. Like SAP, EAT-2 was associated with the SLAM-related receptor 2B4 in NK cells. However, unlike SAP, EAT-2 was an inhibitor of NK… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

MHC-class-I-independent natural-killer-cell self-tolerance

  • V. Kumar, McNerney, M. E. A new self
  • Nat. Rev. Immunol. 5, 363–374
  • 2005

Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244)

  • P Eissmann
  • Blood 105,
  • 2005

Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells

  • Vaidya, S.V
  • J. Immunol
  • 2005

Similar Papers

Loading similar papers…