Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

  title={Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor},
  author={Romain Roncagalli and James E R Taylor and Shaohua Zhang and Xiaochu Shi and Riyan Chen and Mario-Ernesto Cruz-Munoz and Luo Yin and Sylvain Latour and Andr{\'e} Veillette},
  journal={Nature Immunology},
EAT-2 is an adaptor expressed in innate immune cells, including natural killer (NK) cells. It is closely related to the adaptor SAP, which regulates signaling lymphocyte activation molecule (SLAM)–related receptors by recruiting the kinase FynT to the receptors. Here we have studied the function of EAT-2 in NK cells by creating mice lacking or overexpressing EAT-2. Like SAP, EAT-2 was associated with the SLAM-related receptor 2B4 in NK cells. However, unlike SAP, EAT-2 was an inhibitor of NK… CONTINUE READING


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