SH2D1A gene

Known as: SIGNALING LYMPHOCYTE ACTIVATION MOLECULE-ASSOCIATED PROTEIN, SAP, SH2 DOMAIN PROTEIN 1A 
This gene plays roles in proliferation, differentiation and activation of B and T-cells.
National Institutes of Health

Papers overview

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Review
2014
Review
2014
X-linked lymphoproliferative disease (XLP) is a rare primary immunodeficiency affecting approximately 1–2 per 1 million males. A… (More)
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2014
2014
This paper considers the application of genetic and genomic techniques to disease resistance, the interpretation of data arising… (More)
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2004
2004
The signaling lymphocytic activation molecule (SLAM)/CD150 family includes a family of chromosome 1-encoded cell surface… (More)
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Highly Cited
2001
Highly Cited
2001
We have introduced a targeted mutation in SH2D1A/DSHP/SAP, the gene responsible for the human genetic disorder X-linked… (More)
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Highly Cited
2001
Highly Cited
2001
CD150 (SLAM/IPO-3) is a cell surface receptor that, like the B cell receptor, CD40, and CD95, can transmit positive or negative… (More)
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Highly Cited
2000
Highly Cited
2000
The purposes of this study were to determine the frequency of mutations in SH2D1A in X-linked lymphoproliferative disease (XLP… (More)
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Highly Cited
2000
Highly Cited
2000
2B4 is a surface molecule involved in activation of the natural killer (NK) cell-mediated cytotoxicity. It binds a protein termed… (More)
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1999
1999
BACKGROUND The Src homology 2 (SH2) domains of cytoplasmic signaling proteins generally bind phosphotyrosine (pTyr) sites in the… (More)
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Highly Cited
1998
Highly Cited
1998
X-linked lymphoproliferative syndrome (XLP or Duncan disease) is characterized by extreme sensitivity to Epstein-Barr virus (EBV… (More)
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Highly Cited
1998
Highly Cited
1998
X-linked lymphoproliferative syndrome (XLP) is an inherited immunodeficiency characterized by increased susceptibility to Epstein… (More)
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