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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
It is shown that a T-cell-specific, SLAM-associated protein (SAP), which contains an SH2 domain and a short tail, acts as an inhibitor by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region.
Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration
- J. Orange, B. Wang, C. Terhorst, C. Biron
- Biology, MedicineThe Journal of experimental medicine
- 1 October 1995
In vivo treatments with antibodies neutralizing IFN-gamma demonstrated that this factor contributed to theNK cell-mediated antiviral defense and reduced the measured parameters of viral defense to levels indistinguishable from those observed in NK cell-deficient mice.
Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development.
The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease
This review discusses recent findings on the structure and function of proteins of the SAP and SLAM families and considers how these proteins control signal transduction that is initiated by SLAM-related receptors in professional antigen-presenting cells.
SAP couples Fyn to SLAM immune receptors
The crystal structure of a ternary SLAM–SAP–Fyn-SH3 complex reveals that SAP binds the FynT SH3 domain through a surface–surface interaction that does not involve canonical SH3 or SH2 binding interactions.
The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions
It is shown that T cell receptor–induced interleukin (IL)-4 secretion by SLAM−/− CD4+ cells is down-regulated, whereas interferon γ production by CD4+, and that the coreceptor SLAM plays a central role at the interface of acquired and innate immune responses.
SAP controls T cell responses to virus and terminal differentiation of TH2 cells
The aberrant immune responses in SAP-deficient mice show that SAP controls several distinct key T cell signal transduction pathways, which explains in part the complexity of the XLP phenotypes.
The T cell receptor/CD3 complex: a dynamic protein ensemble.
A localized and TCR-independent adhesion provides a stabilizing environment for the subtle ternary inter action, which is dependent upon the fine recognition of all three of its participants.
Recognition of cluster of differentiation 1 antigens by human CD4−CD8>− cytolytic T lymphocyte
- S. Porcelli, M. Brenner, J. Greenstein, C. Terhorst, S. Balk, P. Bleicher
- 5 October 1989
The results suggest that for a subset of T cells, GDI molecules serve a function analogous to that of MHG class I and II molecules.