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SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in vivo, we compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotentExpand
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The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
In addition to triggering the activation of B- or T-cell antigen receptors, the binding of a ligand to its receptor at the cell surface can sometimes determine the physiological outcome ofExpand
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Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration
The presence of natural killer (NK) cells contributes to early defense against murine cytomegalovirus (MCMV) infection. Although NK cells can mediate in vivo protection against MCMV, the mechanism byExpand
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Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development.
Commitment to the T and natural killer T (NKT) cell lineages is determined during alphabeta T cell receptor (TCR)-mediated interactions of common precursors with ligand-expressing cells in theExpand
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The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease
SAP (signalling lymphocytic activation molecule (SLAM)-associated protein) is a T- and natural killer (NK)-cell-specific protein containing a single SH2 domain encoded by a gene that is defective orExpand
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SAP couples Fyn to SLAM immune receptors
SAP (SLAM-associated protein) is a small lymphocyte-specific signalling molecule that is defective or absent in patients with X-linked lymphoproliferative syndrome (XLP). Consistent with its singleExpand
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The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions
Signaling lymphocyte activation molecule (SLAM), a glycoprotein expressed on activated lymphocytes and antigen-presenting cells, has been shown to be a coregulator of antigen-driven T cell responsesExpand
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Recognition of cluster of differentiation 1 antigens by human CD4−CD8>− cytolytic T lymphocyte
HUMAN cluster-of-differentiation 1 (CD1) is a family of cell surface glycoproteins of unknown function expressed on immature thymocytes, epidermal Langerhans cells and a subset of B lymphocytes1–3.Expand
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SAP controls T cell responses to virus and terminal differentiation of TH2 cells
SH2D1A, which encodes signaling lymphocyte activation molecule (SLAM)–associated protein (SAP), is altered in patients with X-linked lymphoproliferative disease (XLP), a primary immunodeficiency.Expand
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The T cell receptor/CD3 complex: a dynamic protein ensemble.
A large body of information about antigen receptors on the surface of T lymphocytes has been gathered in the last five years (1, 2). Expand
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