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SGPP1 gene
Known as:
SPPASE1
, Sphingosine-1-Phosphate Phosphatase 1 Gene
, SPP1
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This gene is involved in sphingosine-1-phosphate degradation.
National Institutes of Health
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Related topics
Related topics
3 relations
Dephosphorylation
Hydrolysis
SGPP1 protein, human
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer's and Parkinson's diseases.
Jin-Fang Chai
,
S. Raichur
,
+9 authors
X. Sim
Human Molecular Genetics
2019
Corpus ID: 204787777
Metabolites are small intermediate products of cellular metabolism perturbed in a variety of complex disorders. Identifying…
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2016
2016
Sphingosine‐1‐phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans
Wei-Ching Huang
,
Jie Liang
,
+9 authors
S. Spiegel
The FASEB Journal
2016
Corpus ID: 205375349
The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) and the kinase that produces it have been implicated in inflammatory…
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Highly Cited
2016
Highly Cited
2016
Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes
T. Fall
,
S. Salihović
,
+15 authors
L. Lind
Diabetologia
2016
Corpus ID: 22896522
Aims/hypothesisIdentification of novel biomarkers for type 2 diabetes and their genetic determinants could lead to improved…
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2016
2016
Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism
R. Dielschneider
,
H. Eisenstat
,
+4 authors
S. Gibson
Leukemia
2016
Corpus ID: 24729496
Lysosome membrane permeabilization (LMP) mediates cell death in a variety of cancer cells. However, little is known about…
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Highly Cited
2015
Highly Cited
2015
Abnormal Expression of miR-21 and miR-95 in Cancer Stem-Like Cells is Associated with Radioresistance of Lung Cancer
Jinghui Zhang
,
Cha Zhang
,
+4 authors
Yuxiang Chen
Cancer Investigation
2015
Corpus ID: 38103238
This study demonstrated that miR-21 and miR-95 expression were significantly higher in the ALDH1+CD133+subpopulation than in the…
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2015
2015
Inhibition of sphingosine-1-phosphate phosphatase 1 promotes cancer cells migration in gastric cancer: Clinical implications.
Xiangyu Gao
,
Lin Li
,
+6 authors
J. Ji
Oncology Report
2015
Corpus ID: 14770439
Sphingosine-1-phosphate (S1P) plays an important role in regulating many biological processes. Sphingosine-1-phosphate…
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Highly Cited
2014
Highly Cited
2014
Tumor Suppressor MicroRNA-27a in Colorectal Carcinogenesis and Progression by Targeting SGPP1 and Smad2
Y. Bao
,
Zhiguo Chen
,
+12 authors
Wancai Yang
PLoS ONE
2014
Corpus ID: 1363975
The aberrant expression of microRNAs (miRNAs) is associated with colorectal carcinogenesis, but the underlying mechanisms are not…
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2014
2014
Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells.
D. Brünnert
,
M. Sztachelska
,
+4 authors
M. Zygmunt
Molecular human reproduction
2014
Corpus ID: 2133676
In the luteal phase, human endometrial stromal cells (HESCs) undergo proliferation, migration and differentiation during the…
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Highly Cited
2013
Highly Cited
2013
miRNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1.
Xiaoyong Huang
,
Samira Taeb
,
+10 authors
Stanley K. Liu
Cancer Research
2013
Corpus ID: 13835024
Radiation resistance poses a major clinical challenge in cancer treatment, but little is known about how microRNA (miR) may…
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Highly Cited
2012
Highly Cited
2012
Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations
A. Demirkan
,
C. V. van Duijn
,
+51 authors
G. Schmitz
PLoS Genetics
2012
Corpus ID: 9104260
Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a…
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