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SGPP1 gene

Known as: SPPASE1, Sphingosine-1-Phosphate Phosphatase 1 Gene, SPP1 
This gene is involved in sphingosine-1-phosphate degradation.
National Institutes of Health

Related topics

Related topics

3 relations
DephosphorylationHydrolysisSGPP1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Sphingosine‐1‐phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans
The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) and the kinase that produces it have been implicated in inflammatory… Expand
2016
2016
Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes
Aims/hypothesisIdentification of novel biomarkers for type 2 diabetes and their genetic determinants could lead to improved… Expand
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2016
2016
Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism
Lysosome membrane permeabilization (LMP) mediates cell death in a variety of cancer cells. However, little is known about… Expand
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2015
2015
Abnormal Expression of miR-21 and miR-95 in Cancer Stem-Like Cells is Associated with Radioresistance of Lung Cancer
This study demonstrated that miR-21 and miR-95 expression were significantly higher in the ALDH1+CD133+subpopulation than in the… Expand
2015
2015
Inhibition of sphingosine-1-phosphate phosphatase 1 promotes cancer cells migration in gastric cancer: Clinical implications.
Sphingosine-1-phosphate (S1P) plays an important role in regulating many biological processes. Sphingosine-1-phosphate… Expand
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Highly Cited
2014
Highly Cited
2014
Tumor Suppressor MicroRNA-27a in Colorectal Carcinogenesis and Progression by Targeting SGPP1 and Smad2
The aberrant expression of microRNAs (miRNAs) is associated with colorectal carcinogenesis, but the underlying mechanisms are not… Expand
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2014
2014
Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells.
In the luteal phase, human endometrial stromal cells (HESCs) undergo proliferation, migration and differentiation during the… Expand
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Highly Cited
2013
Highly Cited
2013
miRNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1.
Radiation resistance poses a major clinical challenge in cancer treatment, but little is known about how microRNA (miR) may… Expand
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Highly Cited
2012
Highly Cited
2012
Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations
Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a… Expand
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Highly Cited
2009
Highly Cited
2009
Evidence for disruption of sphingolipid metabolism in schizophrenia
As the field of glycobiology grows, important roles for glycolipids and glycoproteins in neurological disorders are being… Expand
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