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SGPP1 gene

Known as: SPPASE1, Sphingosine-1-Phosphate Phosphatase 1 Gene, SPP1 
This gene is involved in sphingosine-1-phosphate degradation.
National Institutes of Health

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Related topics

3 relations
DephosphorylationHydrolysisSGPP1 protein, human

Papers overview

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2016
2016
Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism
Lysosome membrane permeabilization (LMP) mediates cell death in a variety of cancer cells. However, little is known about… Expand
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2016
2016
Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans.
The bioactive sphingolipid sphingosine-1-phosphate (S1P) and the kinase that produces it have been implicated in inflammatory… Expand
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2016
2016
Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes
Aims/hypothesisIdentification of novel biomarkers for type 2 diabetes and their genetic determinants could lead to improved… Expand
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2015
2015
Abnormal Expression of miR-21 and miR-95 in Cancer Stem-Like Cells is Associated with Radioresistance of Lung Cancer
This study demonstrated that miR-21 and miR-95 expression were significantly higher in the ALDH1+CD133+subpopulation than in the… Expand
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2015
2015
Association of SPP1 promoter variants with hip osteoarthritis susceptibility in Chinese population.
Three genetic variants in the promoter of SPP1 (secreted phosphoprotein 1) gene have been reported to affect transcriptional… Expand
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Highly Cited
2014
Highly Cited
2014
Tumor Suppressor MicroRNA-27a in Colorectal Carcinogenesis and Progression by Targeting SGPP1 and Smad2
The aberrant expression of microRNAs (miRNAs) is associated with colorectal carcinogenesis, but the underlying mechanisms are not… Expand
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Highly Cited
2013
Highly Cited
2013
miRNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1.
Radiation resistance poses a major clinical challenge in cancer treatment, but little is known about how microRNA (miR) may… Expand
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2013
2013
Sphingosine-1-phosphate Phosphatase 1 Regulates Keratinocyte Differentiation and Epidermal Homeostasis*♦
Background: Sphingosine-1-phosphate phosphatase 1, encoded by Sgpp1, dephosphorylates the signaling lysophospholipid, S1P… Expand
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Highly Cited
2012
Highly Cited
2012
Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations
Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a… Expand
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Highly Cited
2009
Highly Cited
2009
Evidence for disruption of sphingolipid metabolism in schizophrenia.
As the field of glycobiology grows, important roles for glycolipids and glycoproteins in neurological disorders are being… Expand
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