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SERPINA3 gene

Known as: SERPINA3, ALPHA-1-ANTICHYMOTRYPSIN, serpin family A member 3 
This gene is involved in the regulation of neutrophil cathepsin G and mast cell chymase activity.
National Institutes of Health

Related topics

Related topics

5 relations
Protein Degradation InhibitionRegulation of ProteolysisSERPINA3 protein, humanSERPINF2 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity
ABSTRACT Background: Following national and regional recommendations, intravenous lipid emulsion (ILE) has become established in… 
Highly Cited
2010
Highly Cited
2010
Inhibition of Connective Tissue Growth Factor Overexpression in Diabetic Retinopathy by SERPINA3K via Blocking the WNT/β-Catenin Pathway
OBJECTIVE Connective tissue growth factor (CTGF) is a major fibrogenic factor. Increased retinal CTGF levels have been implicated… 
Highly Cited
2009
Highly Cited
2009
Anti-inflammatory and antioxidant effects of SERPINA3K in the retina.
PURPOSE Previous studies by the authors have shown that retinal levels of SERPINA3K, a serine proteinase inhibitor, are decreased… 
Highly Cited
2005
Highly Cited
2005
Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization
Mobilization of hematopoietic progenitor cells into the blood involves a massive release of neutrophil serine proteases in the… 
Review
2005
Review
2005
A review of asthma genetics: gene expression studies and recent candidates.
Recent evidence indicates an important role of inflammation pathways, airways remodeling and epithelium activation in asthma… 
Review
2002
Review
2002
Pharmacogenomics for the treatment of dementia
Alzheimer's's disease (AD) is a genetically complex disorder associated with multiple genetic defects either mutational or of… 
Review
1999
Review
1999
Mevalonate biosynthesis in plants.
I. Synthesis of Mevalonic Acid 107 II. Arabidopsis Contains Two Differentially Expressed Genes Encoding HMGR 107 A… 
Highly Cited
1996
Highly Cited
1996
Polymorphism in AACT gene may lower age of onset of Alzheimer's disease
The ApoE-4 allele is a predisposing factor for late onset Alzheimer's disease (AD), however it is neither necessary nor… 
Highly Cited
1993
Highly Cited
1993
Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1.
Alpha 1-antitrypsin (alpha 1AT; protease inhibitor [PI] locus), alpha 1-antichymotrypsin (alpha 1ACT; AACT locus), corticosteroid… 
Highly Cited
1988
Highly Cited
1988
Factor XIIIa and the classic histiocytic markers in malignant fibrous histiocytoma: a comparative immunohistochemical study.
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