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Intensive blood-pressure lowering in patients with acute cerebral hemorrhage.
TLDR
To determine the therapeutic benefit of intensive BP treatment compared to standard BP treatment in reducing death and disability after 3 months of follow-up among patients with ICH treated within 4.5 hours from onset of symptoms. Expand
Regional variations in the prevalence of multiple sclerosis in French farmers
TLDR
The results may be generalised to the whole French population as there is no convincing evidence of an increased or decreased susceptibility to multiple sclerosis among farmers or persons living in the countryside, which places France among the countries of medium to high prevalence. Expand
Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup
TLDR
Despite clinical evidence comprised mostly of case reports and suboptimal toxicokinetic data, the workgroup recommended extracorporeal removal in the case of severe metformin poisoning. Expand
Treatment for calcium channel blocker poisoning: A systematic review
TLDR
The reported effects of treatments for calcium channel blocker poisoning were mortality and hemodynamic parameters and the risk of bias across studies was high for all interventions and moderate to high for extracorporeal life support. Expand
Extracorporeal Treatment for Lithium Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup.
TLDR
The workgroup concluded that lithium is dialyzable (Level of evidence=A) and made the following recommendations: Hemodialysis is the preferred extracorporeal treatment, but continuous RRT is an acceptable alternative (1D). Expand
Extracorporeal treatment for carbamazepine poisoning: Systematic review and recommendations from the EXTRIP workgroup
TLDR
Despite the low quality of the available clinical evidence and the high protein binding capacity of carbamazepine, the workgroup suggested extracorporeal removal in cases of severe carbazepine poisoning. Expand
Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning*
TLDR
Clinical recommendations regarding the use of ILE in poisoning were only possible in a small number of scenarios and were based mainly on very low quality of evidence, balance of expected risks and benefits, adverse effects, laboratory interferences as well as related costs and resources. Expand
Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults
TLDR
Recommendations for the stepwise management of calcium channel blocker toxicity are offered and include IV calcium in addition to the standard advanced cardiac life-support, lipid-emulsion therapy, and venoarterial extracorporeal membrane oxygenation if available. Expand
Extracorporeal Treatment for Salicylate Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup.
TLDR
Salicylates are readily removed by extracorporeal treatment, with intermittent hemodialysis being the preferred modality, and the signs and symptoms of salicylate toxicity listed warrant extracorporation, as do high concentrations regardless of clinical status. Expand
Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity
TLDR
ILE appears to be effective for reversal of cardiovascular or neurological features in some cases of LA toxicity, but there is currently no convincing evidence showing that ILE is more effective than vasopressors or to indicate which treatment should be instituted as first line therapy in severe LA toxicity. Expand
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