FAQ

SEPT5 wt Allele

Known as: CDCREL1, CDCREL-1, Peanut-Like 1 (Drosophila) Gene 
Human SEPT5 wild-type allele is located in the vicinity of 22q11.21 and is approximately 10 kb in length. This allele, which encodes septin-5 protein… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2016
01219882016

Related topics

Related topics

8 relations
22q11.21Cell Cycle ControlCytokinesisIntracellular Transport
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Broader (1)

SEPT5 gene

Related mentions per year

Related mentions per year

1949-2018
19401960198020002020
SEPT5 wt Allele
Cell Cycle Control
Cytokinesis
Intracellular Transport
Regulation of Exocytosis
SEPT5 gene

Papers overview

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2007
2007
Phosphorylation of adult type Sept5 (CDCrel-1) by cyclin-dependent kinase 5 inhibits interaction with syntaxin-1.
Increasing evidence implicates cyclin-dependent kinase 5 (Cdk5) in neuronal synaptic function. We searched for Cdk5 substrates in… (More)
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2005
2005
RING finger ubiquitin-protein isopeptide ligase Nrdp1/FLRF regulates parkin stability and activity.
Parkin is a ubiquitin-protein isopeptide ligase. It has been suggested that loss of function in parkin causes accumulation and… (More)
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Review
2004
Review
2004
[Etiology and pathogenesis of Parkinson's disease: from mitochondrial dysfunctions to familial Parkinson's disease].
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. It is urgently needed to… (More)
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2004
2004
Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals.
The septins are GTPase enzymes with multiple roles in cytokinesis, cell polarity or exocytosis. The proteins from the mammalian… (More)
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2003
2003
Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1.
Mutations in the parkin gene are linked to autosomal-recessive juvenile parkinsonism (AR-JP). Parkin functions as a ubiquitin… (More)
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Highly Cited
2003
Highly Cited
2003
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons.
Loss-of-function mutations in parkin are the major cause of early-onset familial Parkinson's disease. To investigate the… (More)
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2002
2002
The septin CDCrel-1 is dispensable for normal development and neurotransmitter release.
Septins are GTPases required for the completion of cytokinesis in a variety of organisms, yet their role in this process is not… (More)
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Highly Cited
2000
Highly Cited
2000
Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1.
Parkinson's disease is a common neurodegenerative disorder in which familial-linked genes have provided novel insights into the… (More)
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2000
2000
Differential localization of septins in the mouse brain.
We have carried out a comparative immunohistochemical study on four members of the septin family, CDCrel-1, Septin6, CDC10, and… (More)
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1998
1998
Localization of a novel septin protein, hCDCrel-1, in neurons of human brain.
Synaptic function is critical for cell-cell communication and the characterization of proteins that function during vesicle… (More)
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