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SENP1 gene

Known as: SUMO1/Sentrin Specific Peptidase 1 Gene, SUMO1/sentrin specific peptidase 1, SENTRIN-SPECIFIC PROTEASE FAMILY, MEMBER 1 
This gene is involved in both apoptosis regulation and protein desumoylation.
National Institutes of Health

Related topics

Related topics

7 relations
Caspase ActivationCaspase-Dependent ApoptosisHydrolysisPost-Translational Protein Processing

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma
The deregulation of HGF/c-Met signaling is implicated in epithelial-mesenchymal transition (EMT) and progress of hepatocellular… 
Review
2016
Review
2016
The role of adipose-derived inflammatory cytokines in type 1 diabetes
ABSTRACT Adipose tissue dysfunction correlates with the development of diabetes. Mice with an adipocyte-specific deletion of the… 
2014
2014
Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage
DBC1 is a major inhibitor of SIRT1, which plays critical roles in the control of diverse cellular processes, including stress… 
2014
2014
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9
SUMOylation is a dynamic process which can be reversed by a family of sentrin/SUMO-specific protease (SENPs). Recently, SENP1, a… 
2013
2013
Inhibition of SENP1 induces radiosensitization in lung cancer cells
Lung cancer is one of the most common and lethal types of malignancy. To date, radiotherapy and chemotherapy have been used as… 
2012
2012
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation.
2011
2011
Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors.
2010
2010
SENP1 participates in the dynamic regulation of Elk-1 SUMOylation
The modification of proteins with SUMO (small ubiquitin-related modifier) plays an important role in determining their functional… 
2005
2005
SUMO Modification of the Ets-related Transcription Factor ERM Inhibits Its Transcriptional Activity*
A variety of transcription factors are post-translationally modified by SUMO, a 97-residue ubiquitin-like protein bound… 
Highly Cited
2002
Highly Cited
2002
Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease.
Early during infection, the herpes simplex regulatory protein ICP0 promotes the proteasome-dependent degradation of a number of… 
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