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SEA 0400

Known as: 2-(4-((2,5-difluorophenyl)methoxy)phenoxy)-5-ethoxyaniline, SEA-0400, SEA0400 
National Institutes of Health

Related topics

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2 relations

Broader (2)

Aniline CompoundsPhenyl Ethers

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
A Na+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N‐methyl‐D‐aspartate injection and ischemia–reperfusion
We investigated the expression of Na+/Ca2+ exchanger (NCX) and the functional role of NCX in retinal damage by using NCX1… 
2006
2006
A Selective Inhibitor of Na+/Ca2+ Exchanger, SEA0400, Preserves Cardiac Function and High-Energy Phosphates against Ischemia/Reperfusion Injury
The Ca2+ overload by Ca2+ influx via Na+/Ca2+ exchanger (NCX) is a critical mechanism in myocardial ischemia/reperfusion injury… 
Review
2006
Review
2006
Topics on the Na+/Ca2+ exchanger: responses of Na+/Ca2+ exchanger to interferon-gamma and nitric oxide in cultured microglia.
The Na(+)/Ca(2+) exchanger (NCX) plays a role in regulation of intracellular Ca(2+) levels, but little is known about the… 
2006
2006
Cellular mechanisms responsible for the inotropic action of insulin on failing human myocardium.
2005
2005
Effects of SEA0400, a Na+/Ca2+ exchange inhibitor, on ventricular arrhythmias in the in vivo dogs.
2005
2005
Cardioprotection without cardiosuppression by SEA0400, a novel inhibitor of Na+-Ca2+ exchanger, during ischemia and reperfusion in guinea-pig myocardium.
2004
2004
Forefront of Na + / Ca 2 + Exchanger Studies : Molecular Pharmacology of Na + / Ca 2 + Exchange Inhibitors
The Na/Ca exchanger (NCX) is an ion transporter that exchanges Na and Ca in either Ca efflux or Ca influx mode, depending on… 
Review
2004
Review
2004
Development and application of Na+/Ca2+ exchange inhibitors
The Na+/Ca2+ exchanger (NCX) is an ion transporter that exchanges Na+ and Ca2+ in either Ca2+ efflux or Ca2+ influx mode… 
2004
2004
Effects of SEA0400 on mutant NCX1.1 Na+-Ca2+ exchangers with altered ionic regulation.
SEA0400 (SEA) blocks cardiac and neuronal Na+-Ca2+ exchange with the highest affinity of any known inhibitor, yet very little is… 
Highly Cited
2003
Highly Cited
2003
Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries.
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