SEA 0400

Known as: 2-(4-((2,5-difluorophenyl)methoxy)phenoxy)-5-ethoxyaniline, SEA-0400, SEA0400 
 
National Institutes of Health

Papers overview

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2014
2014
'Classic' cardiotonic steroids (CTSs) such as digoxin and ouabain selectively inhibit Na+, K+ -ATPase (the Na+ pump) and, via Na… (More)
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2011
2011
Collecting duct (CD) endothelin-1 (ET-1) is an important autocrine inhibitor of CD Na(+) reabsorption. Salt loading is thought to… (More)
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2010
2010
Mice with smooth muscle (SM)-specific knockout of Na(+)/Ca(2+) exchanger type-1 (NCX1(SM-/-)) and the NCX inhibitor, SEA0400… (More)
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2010
2010
In vivo studies have suggested that increased beat-to-beat variability of ventricular repolarization duration (BVR) is a better… (More)
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Highly Cited
2008
Highly Cited
2008
Intracellular Ca(2+) waves (CaWs) of cardiomyocytes are spontaneous events of Ca(2+) release from the sarcoplasmic reticulum that… (More)
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2008
2008
BACKGROUND AND PURPOSE The Na(+)/Ca(2+) exchanger (NCX) may play a key role in myocardial contractility. The operation of the NCX… (More)
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2006
2006
The cardioprotective effects of SEA0400, a novel Na(+)-Ca(2+) exchanger inhibitor, were examined in isolated guinea pig… (More)
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Review
2005
Review
2005
The Na(+)-Ca(2+) exchanger (NCX) is involved in regulation of intracellular Ca(2+) concentration. A specific inhibitor of NCX has… (More)
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2004
2004
The sodium-calcium exchanger (NCX) was considered to play an important role in arrhythmogenesis under certain conditions such as… (More)
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2003
2003
KB-R7943 and SEA0400 are Na(+)/Ca(2+) exchanger (NCX) inhibitors with differing potency and selectivity. The cardioprotective… (More)
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