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Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia
Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis
Fasudil hydrochloride improves pathology in mouse models of Alzheimer's disease and spinal muscular atrophy, but there is no evidence that it can affect ALS.
Laxative effects of agarwood on low-fiber diet-induced constipation in rats
- M. Kakino, Shigemi Tazawa, H. Hara
- Medicine, BiologyBMC complementary and alternative medicine
- 15 November 2010
Findings indicate that EEA has a laxative effect, without causing diarrhea, in a rat model of low-fiber diet-induced constipation, and suggest that E EA may be highly effective on constipation as a complementary medicine in humans suffering from life style- induced constipation.
The Experimental and Clinical Pharmacology of Propofol, an Anesthetic Agent with Neuroprotective Properties
- Y. Kotani, M. Shimazawa, S. Yoshimura, T. Iwama, H. Hara
- BiologyCNS neuroscience & therapeutics
- 1 June 2008
Propofol reduces cerebral blood flow and intracranial pressure, is a potent antioxidant, and has antiinflammatory properties, and laboratory investigations revealed that it might also protect brain from ischemic injury.
The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment
PGRN exerted ameliorative effects against I/R-induced inflammation, and these effects may be due to the inhibition of neutrophil recruitment into the I-R brain.
The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis
Glycoprotein nonmetastatic melanoma protein B can be a target for therapeutic intervention for suppressing motor neuron degeneration in ALS, and expression was substantial in the sera of sporadic ALS patients than that of other diseased patients.
Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light
- Yoshiki Kuse, Kenjirou Ogawa, K. Tsuruma, M. Shimazawa, H. Hara
- BiologyScientific reports
- 9 June 2014
Overall, the LED light induced cell damage was wavelength- but not energy-dependent and may cause more severe retinal photoreceptor cell damage than the other LED light.
Comparison of bee products based on assays of antioxidant capacities
- Y. Nakajima, K. Tsuruma, M. Shimazawa, S. Mishima, H. Hara
- Chemistry, MedicineBMC complementary and alternative medicine
- 26 February 2009
Propolis is the most powerful antioxidant of all the bee product examined, and its effect may be partly due to the various caffeic acids it contains.
Intravitreal injection of endothelin-1 caused optic nerve damage following to ocular hypoperfusion in rabbits.