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Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia
Toll-like receptors (TLRs) are signaling receptors in the innate immune system that is a specific immunologic response to systemic bacterial infection. We investigated whether cerebral ischemiaExpand
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Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light
Our eyes are increasingly exposed to light from the emitting diode (LED) light of video display terminals (VDT) which contain much blue light. VDTs are equipped with televisions, personal computers,Expand
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The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an incurable and fatal neurodegenerative disease characterized by the loss of motor neurons. Despite substantial research, the causes of ALS remain unclear.Expand
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The Experimental and Clinical Pharmacology of Propofol, an Anesthetic Agent with Neuroprotective Properties
Propofol (2,6‐diisopropylphenol) is a versatile, short‐acting, intravenous (i.v.) sedative‐hypnotic agent initially marketed as an anesthetic, and now also widely used for the sedation of patients inExpand
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The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment
BackgroundTo improve the clinical outcome of patients who suffered ischemic stroke, cerebral ischemia-reperfusion (I/R) injury is one of the major concerns that should be conquered. InflammatoryExpand
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Laxative effects of agarwood on low-fiber diet-induced constipation in rats
BackgroundAgarwood (Aquilaria sinensis), well known as incense in Southeast Asia, has been used as a digestive in traditional medicine. We investigated the laxative effects of an ethanol extract ofExpand
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Comparison of bee products based on assays of antioxidant capacities
BackgroundBee products (including propolis, royal jelly, and bee pollen) are popular, traditional health foods. We compared antioxidant effects among water and ethanol extracts of Brazilian greenExpand
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Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice
The endoplasmic reticulum (ER) plays an important role in ischemic neuronal cell death. ER stress-related markers [immunoglobulin binding protein (BiP)/glucose-regulated protein (GRP) 78, activatingExpand
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Morphological and Functional Changes in the Retina after Chronic Oxygen-Induced Retinopathy
The mouse model of oxygen-induced retinopathy (OIR) has been widely used for studies of retinopathy of prematurity (ROP). This disorder, characterized by abnormal vascularization of the retina, tendsExpand
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Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo.
Our aim was to determine whether a Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) can protect retinal ganglionExpand
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