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SCH 442416

Known as: 5-amino-7-(3-(4-methoxyphenyl)propyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine, SCH-442416, SCH442416 
National Institutes of Health

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2 relations

Broader (2)

PyrazolesPyrimidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Remote control of movement disorders using a photoactive adenosine A2A receptor antagonist
2018
2018
Behavioral control by striatal adenosine A2A‐dopamine D2 receptor heteromers
G protein‐coupled receptors (GPCR) exhibit the ability to form receptor complexes that include molecularly different GPCR (ie… 
2018
2018
Early changes in transient adenosine during cerebral ischemia and reperfusion injury
Adenosine is an important neuromodulator in the central nervous system, and tissue adenosine levels increase during ischemic… 
Review
2016
Review
2016
Allosteric mechanisms within the adenosine A2A–dopamine D2 receptor heterotetramer
2014
2014
Development of [18F]-labeled pyrazolo[4,3-e]-1,2,4- triazolo[1,5-c]pyrimidine (SCH442416) analogs for the imaging of cerebral adenosine A2A receptors with positron emission tomography.
Cerebral adenosine A2A receptors (A2ARs) are attractive therapeutic targets for the treatment of neurodegenerative and… 
Highly Cited
2011
Highly Cited
2011
On the role of subtype selective adenosine receptor agonists during proliferation and osteogenic differentiation of human primary bone marrow stromal cells
Purines are important modulators of bone cell biology. ATP is metabolized into adenosine by human primary osteoblast cells (HPOC… 
2011
2011
Pharmacological evidence for different populations of postsynaptic adenosine A2A receptors in the rat striatum
2011
2011
Adenosine A2A and A2B receptor expression in neuroendocrine tumours: potential targets for therapy
The clinical management of neuroendocrine tumours is complex. Such tumours are highly vascular suggesting tumour-related… 
2010
2010
Synthesis and evaluation of 1,2,4-triazolo[1,5-c]pyrimidine derivatives as A2A receptor-selective antagonists.
Highly Cited
2009
Highly Cited
2009
The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen‐glucose deprivation in rat CA1 hippocampal slices
Background and purpose:  Activation of adenosine A2A receptors in the CA1 region of rat hippocampal slices during oxygen‐glucose… 
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