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SCA 40

Known as: SCA-40, SCA40 
National Institutes of Health

Papers overview

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Review
1999
Review
1999
Antiproliferative, differentiating and apoptotic effects elicited by imidazo[1,2-a]pyrazine derivatives.
1998
1998
[SCA 40 and derivatives: new bronchodilators in an imidazo(1,2-a)pyrazine series].
Asthma is a complex disease characterised by bronchoconstriction and airways inflammation. Recent advances in medicinal chemistry… 
1997
1997
Bronchodilator and anti-inflammatory activities of SCA40: Studies in human isolated bronchus, human eosinophils, and in the guinea-pig in vivo
There is currently interest in the use of inhibitors of cyclic nucleotide phosphodiesterases (PDE) as potential anti-asthma… 
1997
1997
Antiproliferative effects of imidazo[1,2-a]pyrazine derivatives on the Dami cell line.
1997
1997
In vitro and in vivo effects of SCA40 on guinea pig airways
Abstract SCA40 (6-bromo-8-methylaminoimidazo[1,2-a]- pyrazine-2-carbonitrile), a compound which had been described as an opener… 
1997
1997
Effects of SCA40 on bovine trachealis muscle and on cyclic nucleotide phosphodiesterases.
1996
1996
Effects of SCA40 on human isolated bronchus and human polymorphonuclear leukocytes: comparison with rolipram, SKF94120 and levcromakalim
1 SCA40 (0.1 nM‐0.1 mM) produced concentration‐dependent suppression of the spontaneous tone of human isolated bronchus (‐log… 
1996
1996
Inhibition of phosphodiesterase IV and intracellular calcium levels in human polymorphonuclear leukocytes.
Phosphodiesterase (PDE) isoenzyme type IV is the predominant cyclic AMP hydrolytic activity in polymorphonuclear leukocytes (PMNs… 
1996
1996
Effects of SCA40 on human bronchi and on guinea pig main bronchi in vitro. Comparison with cromakalim
Summary— The aim of this study was to examine the activity of SCA40, a novel charybdotoxin‐sensitive potassium channel opener… 
1993
1993
Cardiovascular effects of SCA40, a novel potassium channel opener, in rats
1 Experiments have been performed to investigate the cardiovascular actions in the rat of SCA40, a novel potassium channel opener… 
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