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SB 705498

Known as: SB-705498, SB705498 
National Institutes of Health

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3 relations

Broader (2)

PyrrolidinesUrea
analogs & derivatives

Papers overview

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2019
2019
The role of urea in neuronal degeneration and sensitization: An in vitro model of uremic neuropathy
Background Uremic neuropathy commonly affects patients with chronic kidney disease, with painful sensations in the feet, followed… 
2018
2018
The research of the possible mechanism and the treatment for capsaicin-induced cough.
2018
2018
Novobiocin, a Newly Found TRPV1 Inhibitor, Attenuates the Expression of TRPV1 in Rat Intestine and Intestinal Epithelial Cell Line IEC-6
Background and Purpose: Novobiocin (NOVO), an ABC transporter inhibitor, decreases intestinal wall permeability of capsaicin (CAP… 
2014
2014
TRPV1 inhibition does not prevent cold dry air-elicited symptoms in non-allergic rhinitis.
BACKGROUND The transient receptor potential vanilloid 1 (TRPV1)-expressing sensory C-fibers may play a role in the development of… 
2012
2012
P152 The Impact of a Selective oral TRPV1 Antagonist in Patients with Chronic Cough
Background Increased expression of TRPV1 receptors in the airways of chronic cough patients and heightened cough responses to… 
2012
2012
P153 The impact of TRPV1 Antagonism on the Treatment of Seasonal Allergic Rhinitis
Background Topical intranasal steroids are widely considered to be the most efficacious pharmacotherapy for the treatment of… 
2011
2011
Efficacy of the TRPV1 antagonist SB-705498 in an MRI guinea pig model of rhinitis
Rationale: Antagonism of nasal TRPV1 receptors is a potential target for inhibition of symptoms associated with rhinitis. Here… 
2011
2011
Pharmacological assessment of the effects of SB-705498 on capsaicin-induced responses in healthy volunteers and patients with non-allergic rhinitis
Rationale: “Nasal hyper-responsiveness” has been proposed as a key mechanism driving nasal symptoms in patients with non-allergic… 
2010
2010
Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water…
Review
2010
Review
2010
TRPS and Migraine
Abstract: Migraine is a highly prevalent, disabling neurovascular disorder characterized by a combination of headache, nausea and… 
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