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Impulsive people have a strong urge to act without thinking. It is sometimes regarded as a positive trait but rash impulsiveness… Expand Cancer anorexia–cachexia syndrome is characterized by decreased food intake, weight loss, muscle tissue wasting and psychological… Expand Serotonin (5-HT) is thought to play an important role in the regulation of behavioral inhibition. Studies manipulating 5-HT… Expand RationaleSerotonin (5-HT) has been linked to impulsivity with recent data suggesting that different receptor sub-types exert… Expand Anxiety-like behaviors are integral features of withdrawal from chronic ethanol exposure. In the experiments in the current study… Expand The 5-HT2C antagonist SB-242084 was examined in various anxiety tests at doses based on reversal of mCPP-induced hypoactivity (0… Expand The possible role of 5-HT1A and 5-HT2C receptors in the anxiety induced by fear, acute treatment with SSRI antidepressants or the… Expand Electrophysiological techniques and in vivo microdialysis were used to investigate the effect of SB 242084, a potent and… Expand The novel, preferential 5-HT2C receptor agonist, Ro 60-0175 ((S)-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine) (2.5 mg,kg… Expand SB 242084 has a high affinity (pKi 9.0) for the cloned human 5-HT2C receptor and 100- and 158-fold selectivity over the closely… Expand