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Simulated seizures and spreading depression in a neuron model incorporating interstitial space and ion concentrations.
Sustained inward currents in neuronal membranes underlie tonic-clonic seizure discharges and spreading depression (SD). It is not known whether these currents flow through abnormally operatingExpand
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Alternatively Spliced Isoforms of TRIP8b Differentially Control h Channel Trafficking and Function
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels (h channels) are the molecular basis for the current, Ih, which contributes crucially to intrinsic neuronal excitability. TheExpand
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Conditions for the triggering of spreading depression studied with computer simulations.
In spite of five decades of study, the biophysics of spreading depression (SD) is incompletely understood. Earlier we have modeled seizures and SD, and we have shown that currents through ionExpand
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Potential New Antiepileptogenic Targets Indicated by Microarray Analysis in a Rat Model for Temporal Lobe Epilepsy
To get insight into the mechanisms that may lead to progression of temporal lobe epilepsy, we investigated gene expression during epileptogenesis in the rat. RNA was obtained from three differentExpand
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Spectral characteristics of the hippocampal EEG in the freely moving rat.
Abstract Rats were implanted chronically with electrodes dorsal and ventral to the pyramidal cell layer of hippocampal CA1 region. Multiple EEG signal with reference to a frontal screw were recordedExpand
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Deep Brain Stimulation in Patients with Refractory Temporal Lobe Epilepsy
Summary:  Purpose: This pilot study prospectively evaluated the efficacy of long‐term deep brain stimulation (DBS) in medial temporal lobe (MTL) structures in patients with MTL epilepsy.
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The N-terminal region of reelin regulates postnatal dendritic maturation of cortical pyramidal neurons
Cajal-Retzius cells, located in layer I of the cortex, synthesize and secrete the glycoprotein reelin, which plays a pivotal role in neuronal migration during embryonic development. Cajal-RetziusExpand
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Extracellular calcium and potassium concentration changes in chronic epileptic brain tissue.
Repetitive electrical stimulation and application of excitatory amino acids lead to decreases in extracellular Ca2+ concentration and to rises in extracellular K+ concentration [( Ca2+]o, [K+]o) withExpand
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Modulation of Sodium Currents in Rat CA1 Neurons by Carbamazepine and Valproate After Kindling Epileptogenesis
Summary: Purpose: To determine the modulation of sodium currents in hippocampal CA1 neurons by carbamazepine (CBZ) and valproate (VPA), before and after kindling epileptogenesis.
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Inhibition of the Multidrug Transporter P‐Glycoprotein Improves Seizure Control in Phenytoin‐treated Chronic Epileptic Rats
Summary:  Purpose: Overexpression of multidrug transporters such as P‐glycoprotein (P‐gp) may play a significant role in pharmacoresistance, by preventing antiepileptic drugs (AEDs) from reachingExpand
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