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SAMHD1 gene

Known as: SAM Domain and HD Domain 1 Gene, monocyte protein 5, Aicardi-Goutieres syndrome 5 
This gene is involved in both signal transduction and the immune response.
National Institutes of Health

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Related topics

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AICARDI-GOUTIERES SYNDROME 5 (disorder)HydrolysisImmune responseImmunity

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SAMHD1 wt Allele

Papers overview

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2020
2020
SAMHD1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination
Sterile alpha motif and histidine‐aspartic acid domain‐containing protein 1 (SAMHD1), a dNTP triphosphohydrolase, regulates the… 
2018
2018
The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592
ABSTRACT SAMHD1 is the major catabolic enzyme regulating the intracellular concentrations of DNA precursors (dNTPs). The S-phase… 
2016
2016
Allosteric Activation of SAMHD1 Protein by Deoxynucleotide Triphosphate (dNTP)-dependent Tetramerization Requires dNTP Concentrations That Are Similar to dNTP Concentrations Observed in Cycling T…
SAMHD1 is a dNTP hydrolase, whose activity is required for maintaining low dNTP concentrations in non-cycling T cells, dendritic… 
2015
2015
SAMHD1 Degradation Enhances Active Suppression of Dendritic Cell Maturation by HIV-1
A hallmark of HIV-1 infection is the lack of sterilizing immunity. Dendritic cells (DCs) are crucial in the induction of immunity… 
2014
2014
Molecular cloning and characterizations of porcine SAMHD1 and its roles in replication of highly pathogenic porcine reproductive and respiratory syndrome virus.
2013
2013
HIV-2 and SIVmac Accessory Virulence Factor Vpx Down-regulates SAMHD1 Enzyme Catalysis Prior to Proteasome-dependent Degradation*
Background: SAMHD1 is counteracted by the HIV-2/SIV virulence factor Vpx, which directs it for degradation. Results: Vpx in… 
2013
2013
Identification of Critical Regions in Human SAMHD1 Required for Nuclear Localization and Vpx-Mediated Degradation
The sterile alpha motif (SAM) and HD domain-containing protein-1 (SAMHD1) inhibits the infection of resting CD4+ T cells and… 
2013
2013
Nucleotide embargo by SAMHD1: a strategy to block retroviral infection.
2012
2012
Co-Evolution of Primate SAMHD1 and Lentivirus Vpx Leads to the Loss of the vpx Gene in HIV-1 Ancestor
Cross-species transmission and adaptation of simian immunodeficiency viruses (SIVs) to humans have given rise to human… 
1993
1993
Isolation and characterization of PSII core complexes from a brown alga, Laminaria saccharina
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