SAMHD1 gene

Known as: SAM Domain and HD Domain 1 Gene, monocyte protein 5, Aicardi-Goutieres syndrome 5 
This gene is involved in both signal transduction and the immune response.

Topic mentions per year

Topic mentions per year

1984-2017
02040608019842017

Papers overview

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Highly Cited
2013
Highly Cited
2013
SAMHD1 restricts HIV-1 replication in myeloid and quiescent CD4(+) T cells. Here, we show that SAMHD1 restriction activity is… (More)
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Highly Cited
2012
Highly Cited
2012
Unlike activated CD4+ T cells, resting CD4+ T cells are highly resistant to productive HIV-1 infection. Early after HIV-1 entry… (More)
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Highly Cited
2012
Highly Cited
2012
SAMHD1 restricts the infection of dendritic and other myeloid cells by human immunodeficiency virus type 1 (HIV-1), but in… (More)
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Highly Cited
2012
Highly Cited
2012
Quiescent CD4+ T lymphocytes are highly refractory to HIV-1 infection due to a block at reverse transcription. Examination of… (More)
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Highly Cited
2012
Highly Cited
2012
Recently, SAMHD1 has come under intense focus as a host anti-HIV factor. SAMHD1 is a dNTP triphosphohydrolase, which leads to the… (More)
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Highly Cited
2011
Highly Cited
2011
Macrophages and dendritic cells have key roles in viral infections, providing virus reservoirs that frequently resist antiviral… (More)
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Highly Cited
2011
Highly Cited
2011
The primate lentivirus auxiliary protein Vpx counteracts an unknown restriction factor that renders human dendritic and myeloid… (More)
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Highly Cited
2011
Highly Cited
2011
SAMHD1, an analogue of the murine interferon (IFN)-γ-induced gene Mg11 (ref. 1), has recently been identified as a human… (More)
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Highly Cited
2011
Highly Cited
2011
The SAMHD1 protein is an HIV-1 restriction factor that is targeted by the HIV-2 accessory protein Vpx in myeloid lineage cells… (More)
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Highly Cited
2009
Highly Cited
2009
Aicardi-Goutières syndrome is a mendelian mimic of congenital infection and also shows overlap with systemic lupus erythematosus… (More)
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