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S32006

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2008-2016
012320082016

Related topics

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2 relations

Broader (2)

IndolesPyridines

Related mentions per year

Related mentions per year

1941-2018
19401960198020002020
S32006
Indoles
Pyridines

Papers overview

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2014
2014
Agomelatine in the tree shrew model of depression: effects on stress-induced nocturnal hyperthermia and hormonal status.
The antidepressive drug agomelatine combines the properties of an agonist of melatonergic receptors 1 and 2 with an antagonist of… (More)
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2014
2014
Like melatonin, agomelatine (S20098) increases the amplitude of oscillations of two clock outputs: melatonin and temperature rhythms.
Depression and biological rhythms disturbances are strongly associated. Agomelatine is an antidepressant with melatoninergic MT1… (More)
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2012
2012
Agomelatine suppresses locomotor hyperactivity in olfactory bulbectomised rats: a comparison to melatonin and to the 5-HT(2c) antagonist, S32006.
The novel melatonergic agonist/5-HT(2C) antagonist agomelatine displays robust antidepressant properties in humans and is active… (More)
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2012
2012
Diverse effects of 5-HT2C receptor blocking agents on c-Fos expression in the rat basal ganglia.
Serotonin(2C) receptors (5-HT(2)C) exert continuous control on the activity of specific populations of neurons in the basal… (More)
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2011
2011
The melatonergic agonist and clinically active antidepressant, agomelatine, is a neutral antagonist at 5-HT(2C) receptors.
The novel antidepressant, agomelatine, behaves as an agonist at melatonergic receptors, and as an antagonist at edited, human… (More)
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2010
2010
Synergistic mechanisms in the modulation of the neurotrophin BDNF in the rat prefrontal cortex following acute agomelatine administration.
OBJECTIVES The aim of this study was to investigate the acute modulation of the neurotrophin Brain-derived neurotrophic factor… (More)
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2010
2010
Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways
Agomelatine is a melatonergic receptor agonist and a 5HT2C receptor antagonist that has shown antidepressant efficacy. In order… (More)
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2009
2009
Mechanisms Contributing to the Phase-Dependent Regulation of Neurogenesis by the Novel Antidepressant, Agomelatine, in the Adult Rat Hippocampus
Agomelatine is a novel antidepressant acting as a melatonergic receptor agonist and serotonergic (5-HT2C) receptor antagonist. In… (More)
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2009
2009
Influence of the novel antidepressant and melatonin agonist/serotonin2C receptor antagonist, agomelatine, on the rat sleep–wake cycle architecture
The novel antidepressant, agomelatine, behaves as an agonist at melatonin MT1 and MT2 receptors and as an antagonist at serotonin… (More)
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2008
2008
S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models
Serotonin (5-HT)2C receptors are implicated in the control of mood, and their blockade is of potential interest for the… (More)
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