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Acute SSRI Administration Affects the Processing of Social Cues in Healthy Volunteers
The results suggest that acute administration of antidepressant drugs may affect neural processes involved in the processing of social information, and may represent an early acute effect of SSRIs on social and emotional processing that is relevant to their therapeutic actions. Expand
Effect of acute antidepressant administration on negative affective bias in depressed patients.
Antidepressant drug administration modulates emotional processing in depressed patients very early in treatment, before changes occur in mood and symptoms, suggesting a mechanism of action compatible with cognitive theories of depression. Expand
Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition.
Short-term administration of two different antidepressant types had similar effects on emotion-related tasks in healthy volunteers, reducing the processing of negative relative to positive emotional material and suggesting a mechanism of action potentially compatible with cognitive theories of anxiety and depression. Expand
Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action
Converging results suggest that antidepressants modulate emotional processing and increase positive emotional processing much earlier than effects on mood, providing a platform for subsequent cognitive and psychological reconsolidation. Expand
Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release
It is indicated that administration of a tyrosine-free amino acid mixture to rats depletes brain tyrosines to cause a decrease in regional brain catecholamine synthesis and release, and dopaminergic neurones appear to be more vulnerable to tyosine depletion than noradrenergic neurone depletion. Expand
Tyrosine depletion attenuates dopamine function in healthy volunteers
Tyrosine depletion in healthy volunteers affected baseline dopamine function on the different measures employed in this study, suggesting that this manipulation may be free of significant side effects when used as a treatment for conditions characterised by dopamine over activity, such as acute mania and schizophrenia. Expand
Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment.
Binding potential values were reduced across many of the regions examined, including frontal, temporal, and limbic cortex in both unmedicated and medicated depressed patients compared with healthy volunteers. Expand
Tryptophan depletion decreases the recognition of fear in female volunteers
A role for serotonin is confirmed in the processing of fear related cues, and in line with previous findings also suggest greater effects of tryptophan depletion in female volunteers. Expand
  • P. Cowen
  • BMJ : British Medical Journal
  • 24 May 2011
Surely one can only agree with Spence’s intriguing insight that modern psychiatry is “merely an intellectual construct,” and the same is true, of course, of other medical disciplines, as well as theExpand