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Acute SSRI Administration Affects the Processing of Social Cues in Healthy Volunteers
Enhancement of serotonin neurotransmission plays an important role in the antidepressant response to agents presently available to treat depression. This response forms the major evidence for theExpand
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Tryptophan depletion in normal volunteers produces selective impairments in learning and memory
The amino-acid L-tryptophan is essential in the synthesis of brain serotonin, and its depletion can lead to a widespread reduction in central serotonergic activity. A placebo-controlled cross-overExpand
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Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action.
BACKGROUND The neuropharmacological actions of antidepressants are well characterised but our understanding of how these changes translate into improved mood are still emerging. AIMS To investigateExpand
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Effect of acute antidepressant administration on negative affective bias in depressed patients.
OBJECTIVE Acute administration of an antidepressant increases positive affective processing in healthy volunteers, an effect that may be relevant to the therapeutic actions of these medications. TheExpand
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Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition.
OBJECTIVE Antidepressants that inhibit the reuptake of serotonin (SSRIs) or norepinephrine (SNRIs) are effective in the treatment of disorders such as depression and anxiety. Cognitive psychologicalExpand
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Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release
Abstract We report the effects of a tyrosine (and phenylalanine)-free amino acid mixture on tyrosine levels, ex vivo catecholamine synthesis and in vivo catecholamine release in brain regions of theExpand
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Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment.
BACKGROUND Pharmacological and postmortem investigations suggest that patients with major depressive disorder have alterations in function or density of brain serotonin1A (5-HT1A) receptors. The aimExpand
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The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers
AbstractRationale. Cognitive impairment is a common feature of depressive illness. While accumulating evidence suggests that brain serotonin (5-HT) pathways play an important role in the neurobiologyExpand
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Tryptophan depletion decreases the recognition of fear in female volunteers
RationaleSerotonergic processes have been implicated in the modulation of fear conditioning in humans, postulated to occur at the level of the amygdala. The processing of other fear-relevant cues,Expand
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  • P. Cowen
  • BMJ : British Medical Journal
  • 24 May 2011
Surely one can only agree with Spence’s intriguing insight that modern psychiatry is “merely an intellectual construct,” and the same is true, of course, of other medical disciplines, as well as theExpand
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