S12363
National Institutes of Health
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S12363 is a potent therapeutic agent with a strong in vitro activity against a variety of tumor types but also a high in vivo…
SummaryS 12363, a new vinca alkaloid derivative, was considerably more cytotoxic to murine L1210 cells and five human tumor cell…
The plasma pharmacokinetics of vinblastine and N-(deacetyl-O-4-vinblastoyl-23)-L-ethyl isoleucinate (VileE) in mice have been…
The growth inhibitory activity of S12363, a new antineoplastic agent which belongs to the vinca alkaloid group incorporating an…
We conducted a phase II study with the new vinca alkaloid derivative S12363 in ten patients with metastatic malignant melanoma…
SummaryThe interactions of S12363 with human plasma proteins have been investigatedin vitro by an erythrocyte partitioning…
L1210 cells treated for 21 hours with S12363, a new vinca alkaloid derivative and the parent compounds (vinblastine, vincristine…