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Drug Binding in Plasma
SummaryThe ligands are generally bound in plasma to a significant extent by several transport proteins (both high and low affinity), irrespective of their endogenous or exogenous origin. The proteinExpand
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Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Renal Transplant Recipients on a New Once-Daily Formulation
The population pharmacokinetic model was further refined by taking into account all of the data from the 41 patients, and the final model was validated using a bootstrap and a visual predictiveExpand
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Population pharmacokinetics of metformin in obese and non-obese patients with type 2 diabetes mellitus
PurposeThe objective of this study was to develop a population pharmacokinetic model and investigate the effect of several demographic covariates on metformin pharmacokinetics in patients with type 2Expand
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Pharmacokinetic Modelling of 5-FU Production from Capecitabine—A Population Study in 40 Adult Patients with Metastatic Cancer
Aims: To model the biotransformation steps of 5-FU production from capecitabine and identify patient characteristics that may influence the drug disposition. Methods: Blood samples and demographicExpand
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A CT scan protocol for the detection of radiographic loosening of the glenoid component after total shoulder arthroplasty
Background and purpose It is difficult to evaluate glenoid component periprosthetic radiolucencies in total shoulder arthroplasties (TSAs) using plain radiographs. This study was performed toExpand
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Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans.
OBJECTIVES The purpose of this study was to characterise the plasma protein binding of BI 1356. METHODS BI 1356 (proposed trade name ONDERO) is a novel dipeptidyl peptidase 4 (DPP-4) inhibitor,Expand
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Pregnancy-Related Effects on Lamivudine Pharmacokinetics in a Population Study with 228 Women
ABSTRACT The aim of this study was to describe lamivudine (3TC) pharmacokinetics (PK) in HIV-infected nonpregnant and pregnant women and their fetuses. Samples were collected according to therapeuticExpand
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Population Pharmacokinetics of Nevirapine in HIV-1-Infected Pregnant Women and Their Neonates
ABSTRACT The aim of the present study was to describe the nevirapine (NVP) pharmacokinetics (PK) in pregnant women and their neonates and to evaluate the transplacental drug transfer andExpand
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Pregnancy-Related Effects on Tenofovir Pharmacokinetics: a Population Study with 186 Women
ABSTRACT According to the European AIDS Clinical Society, tenofovir disoproxil fumarate can be used in HIV-infected pregnant women if started prior to pregnancy, although no data are available on theExpand
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